Changes of Serum IL-17 Th17 and Treg Cells in Patients with Acute Exacerbation of COPD before and after Treatment and the Correlation with Lung Function
WU Guixiong, ZHU Shuiquan, DONG Shufeng, et al
Wuzhou People's Hospital, Guangxi Wuzhou 543002, China
Abstract：Objective: To observe the changes of serum interleukin-17 (IL-17), Th17 cells and regulatory T cells (Treg) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) before and after treatment, and explore their correlation with lung function. Methods: 300 patients with AECOPD (AECOPD group) and 100 healthy controls (control group) were selected. The levels of serum Th17,Treg cells and IL-17 levels were detected by flow cytometry. and lung function was detected to obtain indicators such as the forced expiratory volume in 1s (FEV1), forced vital capacity (FVC) and FEV1/FVC. Results: Serum IL-17, Th17 cells and Th17/Treg ratio in AECOPD group were significantly higher than those in the control group (P<0.05). Serum IL-17, Th17 cells and Th17/Treg ratio in AECOPD group significantly decreased after treatment (P<0.05) while Treg cells increased significantly (P<0.05), with significant differences between groups (P<0.05). Pearson correlation analysis showed that serum Th17, IL-17 and Th17/Treg ratio in patients with AECOPD were negatively correlated with FEV1, FVC and FEV1/FVC before and after treatment (P<0.05) while Treg cells were positively correlated with FEV1, FVC and FEV1/FVC (P<0.05). ROC curve analysis showed that the areas under curves of serum Th17, Treg, Th17/Treg and IL-17 levels for predicting death of patients with AECOPD were 0.840, 0.812, 0.975 and 0.880, respectively. The area under the curve of Th17/Treg was the largest, and there were statistically significant differences, compared with the other three indexes (P<0.05). Conclusion: Serum IL-17, Th17 and Treg are closely related to lung function in patients with AECOPD. They can be used as important indicators for judgement of the condition and prognosis. Besides, the diagnostic efficiency of Th17/Treg is the highest.
伍桂雄, 朱水泉, 董树烽, 沙雯雯. COPD急性加重期患者治疗前后血清IL-17 Th17 Treg细胞变化及其与肺功能的相关性研究[J]. 河北医学, 2020, 26(1): 13-17.
WU Guixiong, ZHU Shuiquan, DONG Shufeng, et al. Changes of Serum IL-17 Th17 and Treg Cells in Patients with Acute Exacerbation of COPD before and after Treatment and the Correlation with Lung Function. HeBei Med, 2020, 26(1): 13-17.
2020, Vol. 26 
冀公网安备13080202000677号