Abstract：Objective: To analyze the changes of serum Microrna-183(mir-183), E-selectin and α1-microglobulin/precursor trypsin inhibitor (AMBP) in patients with gastric cancer and their relationship with clinical pathology. Methods: 96 patients with gastric cancer who treated from January 2016 to January 2017 in our hospital and 30 patients with outpatient health examination were selected at the same time. Then serum levels of miR-183, E-selectin and AMBP between the gastric cancer group and the control group were compared, and the correlation between the above indicators and clinical pathology was analyzed, and the predictive value of gastric cancer diagnosis was also analyzed. Results: Serum levels of miR-183, E-selectin and AMBP in gastric cancer group were higher than the control group, there were a statistically significant difference (P<0.05).The levels of miR-183, E-selectin and AMBP in serum of patients with different TNMⅢ-Ⅳ stages, lymph node metastasis and infiltration depth T3-T4 were higher than those of patients with TNM-Ⅱ stages, no lymph node metastasis and infiltration depth T1-T2, with statistical difference (P<0.05). Serum miR-183, E-selectin and AMBP levels showed no difference among different ages, genders, tumor distribution sites, HP infection and tumor differentiation (P>0.05). The area under the curve of miR-183 was 0.687, and the sensitivity and specificity were 0.833 and 0.625; The area under the E-selectin curve was 0.854, and the sensitivity and specificity were 0.831 and 0.829;The area under the AMBP curve was 0.752, and the sensitivity and specificity were 0.867 and 0.635;The area under the curve was 0.908, and the sensitivity and specificity were 0.900 and 0.843. Conclusion: Serum levels of miR-183, E-selectin and AMBP are correlated with the clinical pathology of gastric cancer, it can also facilitate the diagnosis of gastric cancer, combined monitoring can make up for the deficiency of single index and has high clinical application value.
靳枫, 余少康, 李柱, 潘毅贞, 王树滨. 胃癌患者血清miR-183 E-selectin AMBP的变化及与临床病理的关系[J]. 河北医学, 2019, 25(12): 2094-2098.
JIN Feng, YU Shaokang, LI Zhu, et al. Changes of Serum miR-183, E-selectin and AMBP in Patients with Gastric Cancer and their Relationship with Clinical Pathology. HeBei Med, 2019, 25(12): 2094-2098.
[1] Kulig J, Wallner G, Drews M, et al. Polish consensus on treatment of gastric cancer; update 2017[J]. Pol Przegl Chir,2017,89(5):59~73. [2] Akabah PS, Mocan S, Molnar C, et al. Importance of optical diagnosis in early gastric cancer: a case report of early gastric signet ring cell carcinoma[J]. Niger Clin Pract,2017,20(10):1342~1345. [3] Hedner C, Borg D, Nodin B, et al. Expression and prognostic significance of human epidermal growth factor receptors 1, 2 and 3 in oesophageal and gastric adenocarcinomas preneoadjuvant and postneoadjuvant treatment[J].Clin Pathol,2018 ,71(5):451~462. [4] 王庆,张长乐.E-选择素在胃癌大网膜转移中的作用及意义[J].广东医学,2014,35(4):570~573. [5] Huang H, Han Y, Gao J, et al. High level of serum AMBP is associated with poor response to paclitaxel-capecitabine chemotherapy in advanced gastric cancer patients[J]. Med Oncol, 2013,30(4):748. [6] Ajani JA, Abramov M, Bondarenko I, et al. A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer[J]. Ann Oncol, 2017,28(9):2142~2148. [7] Ikoma N, Cloyd J, Badgwell BD, et al. Clinical features and survival of gastric cancer patients with DNA mismatch repair deficiency[J].Surg Oncol,2018,17(4):707~709. [8] 黄喜顺,邓立新,邱耀辉,等.早期胃癌筛查血清学指标研究进展[J].临床误诊误治,2016,29(8):109~116. [9] 荣维,王浩,宋丽萍.胃癌患者血清中微小RNA分子的特异性表达及其临床意义[J].临床内科杂志,2015,32(2):88~90. [10] 王德韬,申雨晴,马中良,等.miR-183家族在肿瘤中作用机理的最新进展[J].生命的化学,2015,35(6):757~762. [11] 王钧,谢艳,姚茹.胃癌血清microRNA标志物研究[J].胃肠病学和肝病学杂志,2014,23(3):244~246. [12] 操珍,孙俊宁,王菀菀,等.胃癌患者血清多种细胞因子联合检测的临床意义[J].肿瘤研究与临床,2016,28(3):169~173. [13] 季福建,刘选文,于哲,等.E-选择素在胃癌中的表达及其血行转移中作用的研究[J].中国实验诊断学,2015,19(9):1469~1471. [14] Inokuchi M, Higuchi K, Takagi Y, et al. Cadherin 5 is a significant risk factor for hematogenous recurrence and a prognostic factor in locally advanced gastric cancer[J]. Anticancer Res,2017,37(12):6807~6813. [15] 冯君楠,黄昊,寿成超.胃癌患者血清AMBP表达及临床意义[J].中华肿瘤防治杂志,2015,22(6):447~450.
2019, Vol. 25 
冀公网安备13080202000677号