Abstract：Objective: To analyze the diagnostic value of colposcopy combined with thinprep cytological test (TCT) in screening precancerous lesions of cervical cancer. Methods: A total of 735 women who underwent colposcopy and TCT examination in our hospital were selected. To evaluate the coincidence of colposcopy and TCT results with pathological results, and to evaluate the diagnostic efficacy of colposcopy and TCT alone or in combination in screening cervical precancerous lesions. Results: A total of 232 cases were positive in colposcopy and TCT, among which 163 cases were positive in both methods. Histopathological examination was performed on 232 patients, and the results showed 45 cases were negative, including 39 cases with normal cervix and 6 cases with cervicitis. Positive for 187 cases, including the cervical intraepithelial neoplasia (CIN) Ⅰ 70 cases, CIN Ⅱ 64 cases, CIN Ⅲ 48 cases, ductal carcinoma in 5 cases. The results of colposcopy were negative in 56 cases and positive in 176 cases. The consistency coefficient between colposcopy and pathological diagnosis was Kappa=0.565, P<0.05. The TCT findings of 232 cases were within the normal range, including 53 cases of atypical squamous cells of undetermined significance (ASCUS) and above, and 179 cases including ASCUS 73, 54 cases of low-grade squamous intraepithelial lesions (LSIL), 44 cases of high-degree squamous intraepithelial lesions (HSIL), and 8 cases of squamous cell carcinoma (SCC). Using pathological examination results as the gold standard, the consistency coefficient of TCT and pathological diagnosis results Kappa=0.773, P<0.05. The sensitivity, specificity and Yoden index of colposcopy and TCT in the diagnosis of cervical precancerous lesions were 78.61%, 91.44% and 90.91%, 57.78%, 82.22% and 88.89% respectively, and 0.36, 0.74 and 0.80, respectively. Conclusions: Colposcopy and TCT can be used to screen and diagnose the precancerous lesions of cervical cancer.
李娜. 联合检测TCT与阴道镜在宫颈癌前病变诊断中的价值分析[J]. 河北医学, 2019, 25(12): 2071-2075.
LI Na. Analysis of the Value of Combined TCT and Colposcopy in the Diagnosis of Cervical Carcinoma. HeBei Med, 2019, 25(12): 2071-2075.
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2019, Vol. 25 
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