Abstract：Objective: To analyze the efficacy and adverse reactions of compound flumetasone combined with calcipotriol ointment and UVA1 phototherapy in the treatment of nail psoriasis. Methods: 88 patients with nail psoriasis were collected and randomly divided into two groups,with 44 cases in each group. Single group was given calcipotriol ointment and UVA1 phototherapy, and combined group was given compound flumetasone combined with calcipotriol ointment and UVA1 phototherapy, and they were treated for 3 months. The nail severity index, related cytokines, transcription factor mRNA expression, quality of life, and occurrence of adverse reactions were compared between the two groups. Results:There were significant differences in group effects, time effects and interaction effects of NAPSI (P<0.05), and the NAPSI scores in combined group at 1 month and 3 months of treatment were significantly lower than those in single group (P<0.05), and the NAPSI scores in the two groups at 1 month and 3 months of treatment were significantly decreased successively (P<0.05). After treatment, the changes of IL-17, IL-22, IL-10 and INF-γ in combined group were larger than those in single group (P<0.05). After treatment, the decreases of mRNA expressions of RORγt and STAT3 in combined group were greater than those in single group (P<0.05). After treatment, the decrease of DLQI score in combined group was greater than that in single group (P<0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups during treatment (P>0.05). Conclusion:Compound flumetasone combined with calcipotriol ointment and UVA1 phototherapy for nail psoriasis can effectively improve clinical symptoms, regulate serum-related cytokines levels, down-regulate mRNA expressions of transcription factors, and improve quality of life of patients.
孙田, 王强, 王东. 复方氟米松联合卡泊三醇软膏与UVA1光疗治疗甲银屑病的疗效及不良反应分析[J]. 河北医学, 2019, 25(12): 2067-2071.
SUN Tian, WANG Qiang, WANG Dong. Efficacy and Adverse Reactions of compound Flumetasone combined with Calcipotriol Ointment and UVA1 Phototherapy in the treatment of Nail Psoriasis. HeBei Med, 2019, 25(12): 2067-2071.
2019, Vol. 25 
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