Abstract：Objective: To explore the relationship KIF2A LDS and the occurrence, development and biological behavior of RCCC by detecting the protein expression of KIF2A and LSD1 in renal clear cell carcinoma (RCCC) and adjacent non tumor tissues,. Methods: The expression of KIF2A and LSD1 in 120 cases of renal clear cell carcinoma and 40 cases of adjacent non-tumor tissues to renal clear cell carcinoma were detected by immunohistochemistry. Results: The expression of KIF2A in renal clear cell carcinoma (60.83%) was significantly higher than that in non-tumor tissues (32.5%). The difference was statistically significant (P<0.05). The expression of LSD1 in renal clear cell carcinoma (55.0%) was significantly higher than that in non-tumor tissues (30.0%). The difference was statistically significant (P<0.05). The expression of KIF2A in RCCC was significantly higher than that in who / ISUP pathological grade and clinical significance The expression of LSD1 protein in RCCC was correlated with WHO / ISUP pathological grade (P<0.05), but not with clinical stage (P > 0.05). The expression of KIF2A and LSD1 protein was not correlated with gender and age (P > 0.05). The results of correlation test showed that the expression of KIF2A and LSD1 was positively correlated (rs = 0.235, P = 0.010). Conclusion: KIF2A and LSD1 may be involved in the occurrence and development of RCCC and have synergistic effect.
殷凤朝, 李芳, 刘丽辉, 曹赫然, 李珅, 孙超. 肾透明细胞癌中KIF2A LSD1 蛋白表达的相关性研究[J]. 河北医学, 2019, 25(12): 2049-2053.
YIN Fengchao, et al. Study on the Expression of KIF2A and LSD1 in Renal Clear Cell Carcinoma. HeBei Med, 2019, 25(12): 2049-2053.
[1] 朱燕,刘宏斌,杨其昌.等.组织芯片检测Kif2a在乳腺癌中的表达及与预后的相关性[J].南京医科大学学报,2017,37(2):217~219. [2] Kelly AD,Issa JJ. The promise of epigenetic therapy: reprogramming the cancer epigenome[J].Curr Opin Genet Dev,2017,42:68~77. [3] 管文华,项锋钢.RhoA蛋白及驱动蛋白KIF2A与卵巢癌临床病理特征的相关性研究[J].中国现代医学杂志,2019,29(5):29~34. [4] 任艳艳,徐沙沙,张丽,等.肺鳞癌组织Kif2a与MMP-2的表达及其相关性[J].齐鲁医学杂志,2016,31(3):285~293. [5] 罗洞波,高云飞,吕红博,等.食管胃结合部癌组织KIF2A和MTI-MMP表达相关性与临床意义[J].中华肿瘤防治杂志,2017,24(13):894~900. [6] Tian Xie, Xingyu Li, Fei Ye, et al. High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma[J]. Biochemical and Biophysical Research Communications,2018,20(2) :65~72. [7] Li X,Li T,Chen D,et al. Overexpression of lysine -specificdemethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signalingpathway and suppression of the p53 signaling pathway [J]. OncolRep,2016,35(1):584~592. [8] Lin-wen Wu, Dong-mei Zhou, Zuo-yan Zhang,et al. Suppression of LSD1 enhances the cytotoxic and apoptotic effects of regorafenib in hepatocellular carcinoma cells [J]. Biochemical and Biophysical Research Communications,2019.,54(3):852~858. [9] Yang C,Wang W,Liang JX,et al. A rhodium(III)-based inhibitor of lysine-specific histone demethylase 1 as an epigenetic modulator in prostate cancer cells [J].Med Chem,2017,60(6):2597~2603. [10] Liu Y,Wang Y,Chen C,et al. LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer bdemethylating histones at the Vimentin promoter [J]. Oncotarget,2017,8(7):11329~11342. [11] 王洁,汪明云,魏荣富.LSD1在卵巢癌中的表达及临床价值[J].现代肿瘤医学,2018,26(3):346~350. [12] 吴红梅,杨洋,等.LSD1与E-钙黏蛋白在胃癌中的表达及预后意义[J].检验医学与临床,2017,14(8):1122~1125. [13] 陈辉星,陈实,李小燕,等.胰腺癌中Ring1B、LSD1及P16表达及其与预后的关系[J].中国普通外科杂志,2017,26(9):1148~1154. [14] 顾晨文,刘现立.LSD1在人直肠腺癌组织中高表达[J].基础医学与临床,2019,39(1):7~10. [15] 崔彭华,张玉娟,邵雪斋.子宫内膜癌组织LSD1、HE4、CA125及CA19-9变化及临床意义[J].临床误诊误治,2019,32(1):19~22.
2019, Vol. 25 
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