Abstract：Objective: To study the effects of coronary artery tortuosity, coronary atherosclerosis (CA) and diabetes on coronary microvascular disease (CMVD). Methods: A retrospective study was conducted to collect the clinical data of 257 patients with typical angina pectoris symptoms from June 2014 to June 2019 in our hospital, and the clinical data of patients without obvious coronary artery stenosis indicated by coronary angiography were collected. According to the results of resting load myocardial perfusion imaging, 105 patients in group A (without CMVD) and 152 patients in group B (with CMVD). The differences in the basic clinical data, coronary angiography results and echocardiography parameters between the two groups were compared, and the influencing factors of CMVD were analyzed by univariate and multivariate Logistic regression. Results: Compared with group A, the proportion of diabetes history was significantly increased in group B, and the concentrations of homocysteine (Hcy), low-density lipoprotein cholesterol (LDL-C) and hypersensitive C-reactive protein (hs-CRP) were all significantly increased (P<0.01). Compared with group A, the detection rate of CA and coronary artery tortuosity in group B was significantly increased, and the corrected TIMI blood flow frame number was significantly increased (P<0.05). Multivariate Logistic regression analysis showed that CA, diabetes and coronary artery tortuosity were all independent risk factors for patients with CMVD (P<0.01). Conclusion: CA, diabetes and coronary artery tortuosity are all independent risk factors for CMVD in patients with angina pectoris but without obvious coronary artery stenosis, suggesting that CA, diabetes and coronary artery tortuosity are closely related to the occurrence of CMVD.
洪钰锟, 李起栋, 黄丹, 凌宏量, 曹明智, 赵卫云. 冠状动脉迂曲冠状动脉粥样硬化和糖尿病对CMVD发生的影响研究[J]. 河北医学, 2019, 25(12): 2004-2008.
HONG Yukun, LI Qidong, HUANG Dan, et al. Study on Effects of Coronary Tortuosity, Diabetes Mellitus and Coronary Atherosclerosis on the Occurrence of Cmvd. HeBei Med, 2019, 25(12): 2004-2008.
2019, Vol. 25 
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