Curative Efficacy of Omeprazole Combined with Aluminum Sulfatein in the treatment of Chronic Gastritis in Children and Effects on Serum Inflammatory Factors and Immune Function
Abstract：Objective: To study the curative efficacy of Omeprazole combined with aluminum sulfatein in the treatment of chronic gastritis in children and its effects on the serum inflammatory factors and immune function. Methods:165 cases of pediatric chronic gastritis admitted to our hospital from September 2016 to September 2018 were selected for this study, the patients were divided into observation group (n=85) and control group (n=80) according to the simple random grouping method. The control group was treated with sucralfate and the observation group was treated with omeprazole on the basis of the control group. Clinical efficacy, serum interleukin-8 (il-8), interleukin-6 (il-6), tumor necrosis factor alpha (tnf-alpha), immune function and adverse reactions were compared between the two groups. Results:After treatment, the total effective rates of the two groups were 95.29% and 83.75%, respectively, with significant difference (P<0.05). After treatment, inflammatory factors in both groups were significantly improved compared with those before treatment, and serum il-8, il-6 and tnf-alpha levels in the two groups were significantly different after treatment (P<0.05). After treatment, the levels of CD3+, CD4+ and CD8+ in the two groups were significantly improved compared with that before treatment, and the levels of CD3+, CD4+ and CD8+ in the two groups were significantly different after treatment (P<0.05). The total incidence of adverse reactions in the two groups was 9.41% and 13.75%, respectively, with no significant difference (P>0.05). Conclusion: The use of omeprazole and sucralate in children with chronic gastritis has significant curative effect and can effectively improve the level of inflammatory factors and immune function, which is worthy of promotion and application.
王刚祚, 饶媚, 王芳. 奥美拉唑联合硫糖铝治疗慢性胃炎患儿的疗效及对血清炎症因子免疫功能的影响[J]. 河北医学, 2019, 25(12): 1982-1985.
WANG Gangzuo, RAO Mei, WANG Fang. Curative Efficacy of Omeprazole Combined with Aluminum Sulfatein in the treatment of Chronic Gastritis in Children and Effects on Serum Inflammatory Factors and Immune Function. HeBei Med, 2019, 25(12): 1982-1985.
[1] 刘京运,金世禄.慢性萎缩性胃炎患病率与年龄的关系及发病的影响因素[J].川北医学院学报,2017,32(1):152~154. [2] 刘志清,艾耀伟.胃苏颗粒联合三联疗法对慢性胃炎患者血清炎症因子的影响[J].湖北中医药大学学报,2017,19(4):24~27. [3] Makki A M, Aldaqal S M, Alorabi S H, et al. Chronic gastritis in morbidly obese patients with sleeve gastrectomy[J]. Electronic Physician, 2016, 8(1):1786~1790. [4] Shiratori S, Mabe K, Yoshii S, et al. Two cases of chronic gastritis with non-helicobacter pylori helicobacter infection.[J]. Internal Medicine, 2016, 55(14):1865~1869. [5] 黄春,张涛.胃宁散联合奥美拉唑治疗慢性浅表性胃炎的疗效观察[J].现代药物与临床,2017,32(9):1672~1674. [6] 朴仁女,赵冬,阚亮,等.奥美拉唑联合克拉霉素、阿莫西林对老年消化性溃疡患者胃泌素水平与外周血红细胞免疫功能的影响[J].现代生物医学进展,2017,17(8):119~122.
2019, Vol. 25 
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