Abstract：Objective: To detect the levels of serum prealbumin (PA), albumin (ALB) and hemoglobin (HB) in patients with stable chronic obstructive pulmonary disease (COPD) and to analyze their relationships with BODE index, i.e. bodymass index (B), degree of airflow obstruction (O), dyspnea (D), exercise capacity (E). Methods: 120 patients with stable chronic obstructive pulmonary disease hospitalized in the Zhujiajiao People’s Hospital of Qingpu District in Shanghai from January 2015 to November 2018 were selected as the observation group, during the same period, 86 healthy persons who came to Zhujiajiao People’s Hospital of Qingpu District in Shanghai for physical examination were selected as the control group, the BODE index score was determined according to the BODE index score standard, serum albumin level was measured by bromocresol green method, serum prealbumin level was measured by immunoturbidimetry, the hemoglobin level was determined by high iron cyanide method, analyzed the correlations between serum prealbumin, albumin, and hemoglobin levels with BODE levels in patients with stable COPD. Results: The BODE index of the observation group was significantly higher than that of the control group (P < 0.05); the levels of serum prealbumin, albumin, and hemoglobin in the observation group were significantly lower than those in the control group (P < 0.05); the levels of serum prealbumin, albumin, and hemoglobin in patients with BODE index grade 4 were significantly lower than those in patients with grade 1, grade 2, and grade 3 (P < 0.05), the levels of serum prealbumin, albumin, and hemoglobin in grade 3 patients were significantly lower than those in grade 1 and grade 2 patients (P < 0.05), the levels of serum prealbumin, albumin, and hemoglobin in grade 2 patients were significantly lower than those in grade 1 patients (P < 0.05); serum prealbumin, albumin, and hemoglobin levels in patients with stable COPD were negatively correlated with BODE index (P < 0.05). Conclusion: The levels of serum prealbumin, albumin, and hemoglobin in patients with stable COPD were significantly decreased, serum prealbumin, albumin, and hemoglobin levels were negatively correlated with BODE index, it may be an effective index for predicting the condition of COPD patients in stable stage.
赖寿兰, 李巍立, 王卫方, 陆小芳, 彭锦贵, 张飞, 杜春玲. COPD稳定期患者血清前白蛋白白蛋白及血红蛋白水平与BODE指数的关系[J]. 河北医学, 2019, 25(11): 1809-1813.
LAI Shoulan, LI Weili, WANG Weifang, et al. Relationships Between Serum Prealbumin Albumin and Hemoglobin Levels with BODE Index in Patients with Stable COPD. HeBei Med, 2019, 25(11): 1809-1813.
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2019, Vol. 25 
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