Changes and Clinical Significance of Serum BGP and AKP Levels in Patients with Diabetes Mellitus before and after Artificial Dental Implant Restoration
XU Haifeng, et al
Dalian Second People’s Hospital, Liaoning Dalian 116011, China
Abstract：Objective: To explore the changes and clinical significance of serum osteocalcin (BGP) and alkaline phosphatase (AKP) levels in patients with diabetes mellitus (DM) before and after artificial dental implant restoration. Methods: A total of 106 patients with DM who underwent artificial dental implant restoration from June 2014 to June 2017 were selected for the study. According to the glycemic control, they were divided into glycemic control group (n=66) and poor glycemic control group (n=40). And 50 healthy people with artificial dental implant restoration treated in the same period were selected as control group. The levels of BGP and AKP in each group were evaluated before operation and at 6 months after operation, and the probing depth (PD) and depth of bone loss (DSB) were compared at 6 months after operation and at 1 year after operation. The incidence rate of inflammation around implant was recorded. Results: The levels of BGP and AKP in glycemic control group and poor glycemic control group at each time point were higher than those in control group (P<0.05). Thelevels of BGP and AKP were increased first and then decreased at the time period from before operation to 1 year after operation in glycemic control group and poor glycemic control group (P<0.05), and thelevels of BGP and AKP in poor glycemic control group at each time point were higher than those in glycemic control group (P<0.05), and there were no interactions of different groups and time in the BGP and AKP (P>0.05). The PD level at 1 year after operation was higher than that at 6 months after operation in glycemic control group and poor glycemic control group (P<0.05), and there was no significant difference in control group between at 6 months after operation and at 1 year after operation (P>0.05), and the difference between the two time points in poor glycemic control group was higher than that in glycemic control group and control group (P<0.05), and the difference between the two time points in glycemic control group was higher than that in control group (P<0.05). At 1 year after operation, the DSB levels in the three groups were higher than those at 6 months after operation (P<0.05), and the difference between the two time points in poor glycemic control group was higher than that in glycemic control group and control group (P<0.05), and the difference between the two time points in glycemic control group was higher than that in control group (P<0.05). The incidence rate of inflammation around implant in poor glycemic control group was higher than that in glycemic control group and control group (P<0.05), and there was no significant difference in the incidence rate of inflammation around implant between glycemic control group and control group (P>0.05). Conclusion: DM can have a variety of negative effects on dental implants. DM patients should actively control blood glucose after dental implant surgery so as to improve the prognosis of dental implants.
徐海峰, 迟丹丹. 糖尿病患者人工种植牙修复手术前后血清BGP AKP水平变化及其临床意义[J]. 河北医学, 2019, 25(11): 1786-1790.
XU Haifeng, et al. Changes and Clinical Significance of Serum BGP and AKP Levels in Patients with Diabetes Mellitus before and after Artificial Dental Implant Restoration. HeBei Med, 2019, 25(11): 1786-1790.
2019, Vol. 25 
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