Effect of Fire Needle combined with Sodium Hyaluronate Injection Intra-articular Injection on Lysholm Score and TLR4 Concentration in Peripheral Blood of Patients with Knee Osteoarthritis
YU Ruijie, LIU Yanwei, et al
Affiliated Hospital of Chengde Medical, Hebei Chengde 067000, China
Abstract：Objective: To observe the influence on Lysholm score the TLR4 concn of peripheral blood on the method of fire needles combined with interarticular injection of sodium hyaluronate in the treatment of knee osteoarthritis. Methods: 80 patients with knee osteoarthritis were randomly divided into treatment group and control group. The treatment group was treated with fire needle combined with sodium hyaluronate injection intra-articular injection. The control group was treated with sodium hyaluronate injection alone intra-articular injection. The changes of Lysholm score and TLR4 concentration in peripheral blood were compared before treatment, 5 and 12 weeks after treatment. Results: At 5 weeks and 12 weeks after treatment, the Lysholm score of knee joint in treatment group and control group was compared (P=0.000, P=0.000), and the TLR4 concentration in peripheral blood of treatment group and control group was compared (P=0.000, P=0.000). Conclusion: Fire needle combined with sodium hyaluronate intra-articular injection can improve Lysholm score, reduce TLR4 concentration in blood, alleviate knee pain and improve knee function.
于瑞杰, 刘艳伟, 孟爱霞, 杜志峰, 李连泰, 王书君. 火针联合玻璃酸钠注射液关节腔注射对膝骨关节炎患者Lysholm评分和外周血TLR4浓度的影响[J]. 河北医学, 2019, 25(10): 1753-1756.
YU Ruijie, LIU Yanwei, et al. Effect of Fire Needle combined with Sodium Hyaluronate Injection Intra-articular Injection on Lysholm Score and TLR4 Concentration in Peripheral Blood of Patients with Knee Osteoarthritis. HeBei Med, 2019, 25(10): 1753-1756.
[1] Lanas A, Tornero J, Zamorano JL. Asessment of gastrointestinal and cardiaovascular risk in patients with osteoarthritis who require NSAIDs: the LOGICA study[J]. Ann Rheum Dis, 2010, 69(8): 1453~1458. [2] 李行星,窦强兵,王启伟,等.关节镜治疗早期膝骨关节炎疗效的影响因素分析[J].实用骨科杂志,2016,22(5):403~406. [3] 吴东海,王国春.临床风湿病学[M].北京:人民卫生出版社,2008.516. [4] 陈国华,邵建赟,何健,等.成人大骨节病髌骨稳定性与Lysholm膝关节功能评分的多重回归分析[J].中华地方病学杂志,2017,36(7):477~481. [5] 王晓玲,王芗斌,侯美金,等.温针灸治疗膝骨关节炎:随机对照研究[J].中国针灸,2017,37(5):457~462. [6] 顾海峰,毕擎,孟可馨,等.关节镜下360度去神经化治疗膝关节骨关节炎85例[J].中华创伤杂志,2014,30(6):555~559. [7] 刘新,黄文瑶,李卫国,等.TLR-4、IL-1与膝骨关节炎相关性的临床研究[J].中华关节外科杂志:电子版,2013,7(4):228~230. [8] Nguyenc,Lefevre-colaumm,Poiraudeaus,et al. Evidence and recommendations for use of intr-articular in jections for knee osteoarthritis[J]. Ann Phys Rehabil Med,2016,59(3):184~189. [9] 李晶晶,张英,眭明红.火针对类风湿性关节炎大鼠痛阈及IL-1、TNF-α影响的实验研究[J].上海针灸杂志,2016,35(5):583~587.
2019, Vol. 25 
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