Effects of Nifedipine Sustained Release Tablets Combined with Cinepazide Maleate on Lipid Level, Cardiac Function and Endothelial Diastolic Function in Elderly Patients with Coronary Heart Disease Complicated with Hypertension
JI Hongye, LI Na, LI Lianjie, et al
The 983 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Tianjin 300142, China
Abstract：Objective: To investigate the effects of nifedipine sustained-release tablets combined with cinepazide maleate on blood lipid levels, cardiac function and endothelium dilation function in elderly patients with coronary heart disease and hypertension. Methods: 102 elderly patients with coronary heart disease and hypertension were divided into observation group and control group by random number table method. The control group was given irbesartan hydrochlorothiazide dispersible tablets and nitrendipine tablets for oral administration. The observation group was given nifedipine sustained-release tablets for oral administration cinepazide maleate injection therapy. The 24h mean systolic blood pressure (24hmSBP), 24h diastolic blood pressure (24hmDBP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels, left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), endothelium-dependent dilation (EDD) and non-endothelium dependent dilatatio (NEDD) were measured before and after treatment. The antihypertensive effect was evaluated. The occurrence of adverse cardiovascular events was statistically analyzed. Results: The total antihypertensive response rates in the observation group and the control group were 96.08% and 88.24%, respectively. There was no significant difference between the two groups (P>0.05). After treatment, 24hmSBP, 24hmDBP, TC, TG and LDL-C were significantly decreased (P<0.05), while HDL-C level was increased. The increase or decrease in the observation group was greater than that in the control group (P<0.05). After treatment, LVEF, EDD AND NEDD in the observation group were significantly higher than those in the control group (P<0.05), while LVEDD and LVESD were significantly lower than thosein the control group (P<0.05). The incidence of adverse cardiovascular events during treatment period in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Nifedipine sustained-release tablets combined with cinepazide maleate can improve endothelial diastolic function, cardiac function and blood lipid levels in elderly patients with coronary heart disease and hypertension, with relatively better antihypertensive effect, which can reduce occurrence risk of cardiovascular events.
姬洪叶, 李娜, 李连杰, 贾从康. 硝苯地平缓释片联合马来酸桂哌齐特对老年冠心病合并高血压患者血脂水平心脏功能及内皮舒张功能的影响[J]. 河北医学, 2019, 25(10): 1647-1650.
JI Hongye, LI Na, LI Lianjie, et al. Effects of Nifedipine Sustained Release Tablets Combined with Cinepazide Maleate on Lipid Level, Cardiac Function and Endothelial Diastolic Function in Elderly Patients with Coronary Heart Disease Complicated with Hypertension. HeBei Med, 2019, 25(10): 1647-1650.
2019, Vol. 25 
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