Abstract：Objective: To investigate the relationship between the serum levels of IL-33 & IL-35 and cardiopulmonary function in patients with stable chronic obstructive pulmonary disease(COPD). Methods: 77 patients with COPD in Department of Respiratory Medicine of Danzhou People's Hospital from March 2017 and September 2018 were divided into stable chronic obstructive pulmonary disease group(n=46) and acute exacerbation chronic obstructive pulmonary disease group (n=31) according to the clinical diagnosis, and 40 normal subjects who underwent a physical examination during this period were included as normal group. Serum IL-33 and serum IL-35 were detected by enzyme-linked immunosorbent assay (ELISA). Results: Serum IL-33 levels in the case group were significantly higher than those in the normal group, and the acute exacerbation chronic obstructive pulmonary disease group was significantly higher than the stable chronic obstructive pulmonary disease group, and the difference was statistically significant (P<0.05). The serum IL-35 level in the case group was significantly lower than that in the normal group, and the acute exacerbation chronic obstructive pulmonary disease group was significantly lower than the stable chronic obstructive pulmonary disease group, and the difference was statistically significant (P<0.05). In the case group, the serum IL-33 level of patients with cardiopulmonary function I-II was significantly lower than that of patients with III-IV(P<0.05), and the serum IL-35 level was significantly higher than that of patients with III-IV(P<0.05). Serum IL-33 was negatively correlated with cardiopulmonary function (P<0.05), and serum IL-35 was positively correlated with cardiopulmonary function in Case group (P<0.05). Conclusions: The serum level of IL-33 in patients with stable chronic obstructive pulmonary disease is lower than that of patients with acute exacerbation COPD, while the serum level of IL-35 is higher. Serum IL-33 is negatively correlated with cardiopulmonary function, while serum IL-35 is positively correlated with cardiopulmonary function. The both have a certain influence on the clinical symptoms of patients with stable chronic obstructive pulmonary disease.
王生成, 杨祚明, 蔡潇阳, 吴飞, 王晓峰. 血清IL-33 IL-35水平与稳定期慢性阻塞性肺疾病患者心肺功能的关系[J]. 河北医学, 2019, 25(10): 1616-1619.
WANG Shengcheng, et al. Relationship Between the Serum Levels of IL-33 & IL-35 and Cardiopulmonary Function in Patients with Stable COPD. HeBei Med, 2019, 25(10): 1616-1619.
[1] Silver JS, Kearley J, Copenhaver AM, et al. Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs[J]. Nat Immunol, 2016, 17(6):626~635. [2] 丁宁,王胜.慢性阻塞性肺疾病发病机制最新研究进展[J].临床肺科杂志,2016,21(1):133~136. [3] 谢柏梅,敬梅,张彦海,等.慢性阻塞性肺疾病临床问卷对稳定期慢性阻塞性肺疾病生活质量的评价[J].解放军医药杂志,2017,29(4):41~44. [4] 汪春荣,邱士军,沈比先,等.稳定期慢性阻塞性肺疾病患者脑灰质体积的改变[J].中国医药导报,2016,13(28):60~63. [5] Karloh M, Fleig Mayer A, Maurici R, et al. The COPD assessment test: what do we know so far: a systematic review and meta-analysis about clinical outcomes prediction and classification of patients into GOLD stages[J]. Chest, 2016, 149(2):413~425. [6] 黄邓高,王婵,陈扬,等.IL-35在肺炎支原体感染患者血清的表达水平及在不同性别、年龄的差异[J].山西医科大学学报,2017,48(7):698~701. [7] 王晨,李俏俏,叶舒婷,等.胸腺肽α1治疗对老年慢性阻塞性肺疾病急性加重期患者白细胞介素-33水平及免疫功能的影响[J].中国慢性病预防与控制,2017,25(6):450~452. [8] 林玛丽,蔡旭龙,冯巍巍,等.白细胞介素-33在慢性呼吸系统疾病中的作用研究进展[J].广西医学,2017,39(7):1053~1056.
2019, Vol. 25 
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