Abstract：Objective: To observe the effect of different dosages of dizocine in patients undergoing general anesthesia during laparoscopic surgery under BIS monitoring. Methods: 76 patients undergoing elective laparoscopic surgery in our hospital from February 2017 to May 2018 were prospectively selected and randomly divided into two groups according to the digital random table method. The low dose group (38 cases) was given 0.10 mg/kg of dizosin combined with propofol, and the high dose group (38 cases) was given 0.15 mg/kg of dizosin combined with propofol. The changes of hemodynamics, time index, propofol dosage, incidence of restlessness and adverse reactions during anesthesia were compared between the two groups. Results: In hemodynamic indexes, MAP, HR and SpO2 were decreased in both groups compared with T0 (t=13.818、6.059、12.821、4.775、33.466、12.903,P<0.05). T2 and T1 MAP, HR, SpO2 increased (t=6.539、5.695、4.060、3.089、29.878、15.137,P<0.05). Group 2 sets of patient groups, the high dose group T1, T2 has a significantly higher SpO2 than the simultaneous low dose group (t=12.821、3.627,P<0.05). 2 groups of patients in the induction time, awake time and directional force recovery time time on indicators had no significant difference (P＞0.05). But high doses of propofol are significantly lower than the low dose group (t=8.256,P＜0.05). There was no significant difference in the incidence of early agitation and adverse reflux rate between the two groups (P＞0.05). Conclusion: Dizosin can effectively control hemodynamics, alleviate stress response and reduce the dosage of propofol, while 0.1 mg/kg of Dizosin can effectively reduce the incidence of restlessness with fewer adverse reactions.
王芳. BIS监测下不同剂量地佐辛应用于腹腔镜手术全身麻醉患者的效果观察[J]. 河北医学, 2019, 25(9): 1560-1564.
WANG Fang. Effect of Different Doses of Dizosin Under BIS Monitoring in Patients undergoing General Anesthesia for Laparoscopic Surgery. HeBei Med, 2019, 25(9): 1560-1564.
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2019, Vol. 25 
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