Comparison of Effects and Safety of Hydrochlorothiazide or Indapamide Combined with Benazepril in the treatment of Patients with Hypertension Complicated with Heart Failure
REN Lanfang, GE Biao, ZHAO Xianjie
Inner Mongolia Baotou Steel Hospital, Inner Mongolia Baotou 014010, China
Abstract：Objective: To compare the effects and safety of hydrochlorothiazide or indapamide combined with benazepril in the treatment of patients with hypertension and heart failure. Methods: 120 patients with hypertension and heart failure from January 2016 to July 2018 were selected and randomly divided into two groups. Control group (60 cases) was given hydrochlorothiazide combined with benazepril, and observation group (60 cases) was given indapamide combined with benazepril, and they were treated for 12 w. The changes of diastolic blood pressure, systolic blood pressure and 6min walking distance before and after treatment were compared between the two groups. The heart function heart rate, left ventricular early diastolic and advanced diastolic blood flow peak velocity ratio (E/A), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESd) and left ventricular end-diastolic diameter (LVEDd) were evaluated. The levels of serological indicators of serum endothelin 1, cortisol, brain natriuretic peptide, angiotensin II (Ang II) and norepinephrine (NE) and oxidative stress indicators of malondialdehyde (MDA), lipid hydrogen peroxide (LHP), glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) were detected. The incidence rate of adverse reactions was analyzed in the two groups. Results: The systolic blood pressure, diastolic blood pressure, E/A, LVESd and LVEDd index index, levels of serum endothelin 1, cortisol, brain natriuretic peptide, NE, Ang II, MDA and LHP in observation group were decreased significantly after treatment. The 6min walking distance was significantly prolonged. The LVEF, GSH-Px level and T-AOC index were significantly increased (P<0.05). The adverse reactions of the two groups were mainly hyponatremia, hypokalemia and hyperuricemia (P>0.05). Conclusions: Indapamide combined with benazepril in the treatment of hypertension patients with heart failure is better than hydrochlorothiazide combined with benazepril, the total effective rate is higher.
任兰芳, 葛彪, 赵显杰. 氢氯噻嗪和吲达帕胺分别联合贝那普利对高血压伴心衰患者效果及安全性对比[J]. 河北医学, 2019, 25(9): 1484-1488.
REN Lanfang, GE Biao, ZHAO Xianjie. Comparison of Effects and Safety of Hydrochlorothiazide or Indapamide Combined with Benazepril in the treatment of Patients with Hypertension Complicated with Heart Failure. HeBei Med, 2019, 25(9): 1484-1488.
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2019, Vol. 25 
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