Abstract：Objective: To investigate the value of combined detection of pepsinogen-I (PG-I), gastrin-17 (G-17) L and Toll-like receptors (TLR4) in peripheral blood in the diagnosis of early laryngeal cancer. Methods: 270 cases of suspected laryngeal cancer and 90 cases of health check-up were selected from January 2013 to May 2017 in our hospital. The levels of PG-Ⅰ and G-17 in serum of the three groups were detected by enzyme linked immunosorbent assay (ELISA), and (peripheral blood mononuclear cell, in peripheral blood mononuclear cells (PBMC) was measured by real-time fluorescence quantitative polymerase chain reaction (real-time polymerase chain reaction,RT-PCR). TLR4 mRNA expression in PBMC. Results: The level of PG-I in vocal cord polyp group was significantly lower than that in healthy control group (P < 0.05), while that in laryngeal cancer group was much lower than that in other two groups (P < 0.05); there was no significant difference between healthy control group and vocal cord polyp group (P > 0.05), and the level of G-17 in laryngeal cancer patients was significantly higher than that in healthy control group and vocal cord polyp group (P < 0.05). The expression of TLR4 in cancer group was significantly higher than that in vocal cord polyp group and polyp group, and the difference was statistically significant (P < 0.05). The sensitivity and negative predictive value of combined detection of three indicators were significantly higher than that of single indicator detection (P < 0.05). Conclusion: The concentration of PGI and G-17 in peripheral serum and the expression of TLR4 in PBMC are of great significance for the diagnosis and differentiation of early laryngeal cancer. The combined detection method can significantly improve the diagnostic efficiency.
张义, 王志平, 白洁, 许尧生. 外周血胃蛋白酶原Ⅰ胃泌素-17及TOLL样受体联合检测对早期喉癌的诊断价值[J]. 河北医学, 2019, 25(9): 1431-1434.
ZHANG Yi, WANG Zhiping, BAI Jie, et al. The Diagnosis Valne of Combined Detection of Pepsinogen I Gastrin-17 and TOLL-like Receptors in Peripheral Blood in Early Laryngeal Cancer. HeBei Med, 2019, 25(9): 1431-1434.
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2019, Vol. 25 
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