Abstract：Objective: To study the application effects of cimetidine and interferon combined with zinc supplement in the treatment of rotavirus infectious diarrhea in children. Methods:180 children patients with rotavirus infectious diarrhea admitted to our hospital from January 2017 to January 2018 were randomly divided into observation group (cimetidine + interferon+zinc supplement, n=90) and control group (cimetidine+interferon, n=90). The treatment effects were observed in the two groups. Results:The stool recovery time, dehydration correction time and body temperature recovery time in observation group were significantly shorter than those in control group (P<0.05). After 3 d of treatment, the negative conversion rate of fecal rotavirus antigen in observation group was significantly higher than that in control group (P<0.05), and the effective rate of treatment was significantly better than that in control group (P<0.05). After 10 d of treatment, the blood zinc levels in the two groups were significantly higher than those before treatment (P<0.05), and the increase in observation group was significantly greater than that in control group (P<0.05), and the blood zinc level in observation group after treatment was significantly higher than that in control group (P<0.05). At 3 months of telephone follow-up, the recurrence rate was 8.89% in observation group and was 20.00% in control group, and there was a significant difference in the recurrence rate between the two groups (χ2=4.23, P<0.05). Conclusions: Zinc supplementation with cimetidine and interferon has a good application value in children with RV infectious diarrhea. It can alleviate the clinical symptoms of children in a short time, promote the negative reaction of RV antigen, improve the treatment effect and reduce the recurrence rate in later period. It is worthy of clinical promotion.
王导利, 王茜, 何阿玲. 西咪替丁与干扰素联合补锌治疗小儿轮状病毒感染性腹泻的疗效分析[J]. 河北医学, 2019, 25(8): 1371-1373.
WANG Daoli, WANG Qian, HE Aling. Analysis on Efficacy of Cimetidine and Interferon combined with Zinc Supplement in treatment of Rotavirus Infectious Diarrhea in Children. HeBei Med, 2019, 25(8): 1371-1373.
2019, Vol. 25 
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