Abstract：Objective: To study the efficacy and safety of febuxostat combination withalprostadil in treatment of chronic renal failure and influence on hyperuricemia(UA) and hemorheology. Methods: 90 patients of chronic renal failure who received therapy from February 2015 to February 2018 in our hospital were selected as research objects,theywere divided into observation group (50 cases) and control group (40 cases) by simple random number table method,on the basis of routine treatment, the control group was treated with febuxostat, and the observation group was treated with Alprostadil for 8 weeks.The clinical efficacy, laboratory indexes, hemorheological changes and adverse reactions of the two groups were compared.Results: After treatment, the total effective rate of the observation group was significantly higher than those in the control group(P<0.05); there were significant differences in urea nitrogen (BUN), serum creatinine (Scr), 24-hour urinary protein, UA, whole blood high shear viscosity, whole blood low shear viscosity and plasma viscosity between groups at interblock·different time points(P<0.05);in the observation group, there were 2 cases of redness in the injection site during the intravenous injection of alprostadil, and there were no nausea and vomiting, obvious abnormal liver function, joint pain and other adverse reactions during the treatment of the two groups. Conclusion: Febuxostat combination withalprostadil is well for chronic renal failure, which can effectively improve blood hypercoagulability and renal function, reducing UA expression, and without increasing adverse drug reactions and has high clinical value.
李治成, 唐志刚, 郑巧, 李培莉. 非布司他联合前列地尔治疗慢性肾衰竭的疗效及高尿酸血症对血液流变学的影响[J]. 河北医学, 2019, 25(8): 1336-1339.
LI Zhicheng, TANG Zhigang, ZHENG Qiao, et al. Efficacy and Safety of Febuxostat Combination with Alprostadil in Treatment of Chronic Renal Failure and Influence Onhyperuricemia Andhemorheology. HeBei Med, 2019, 25(8): 1336-1339.
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2019, Vol. 25 
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