Abstract：Objective: To study the curative efficacy of milrinone combined with dopaminein treatment of chronic heart failure and effects on Cystatin C(CysC), N-terminal B type natriuretic peptide precursor(NT-proBNP), interleukin-6(IL-6) levels. Methods: 65 patients of chronic heart failure who received therapy from June 2017 to September 2018 in our hospital were selected as research objects, they were divided into observation group (35 cases) and control group (30 cases) by simple random number table method. The control group was given routine treatment, while the observation group was given milrinone combined with dopamine without digitalis preparation, they were continuous treatment for 7d. The clinical efficacy, the changes of serum CysC, NT-proBNP, IL-6 and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate in the observation group was significantly higher than those in the control group(P<0.05); there were significant differences in the interaction of left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), serum CysC, NT-proBNP and IL-6 between groups at interblock·different time points(P<0.05); there were no adverse reactions such as abnormal liver and kidney function, abnormal blood and urine routine, and 1 case of ventricular premature contraction in the observation group. Conclusion: Milrinone combined with dopaminein is well for chronic heart failure, which can effectively reduce the expression of serum CysC, NT-proBNP and IL-6, the clinical application value is high.
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2019, Vol. 25 
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