Abstract：Objective: To investigate the effects of topiramate and levetiracetam on the bone metabolism in children with school-age epilepsy. Methods: A total of 82 cases of children with school-age epilepsy who were treated in our hospital from October 2014 to October 2017 were randomly divided into group A and group B, 41 cases in each group. The two groups of children were treated with topiramate and levetiracetam, respectively. The clinical efficacy and the effect on bone metabolism were compared between the two groups. Results: The total effective rate of clinical treatment in group A and group B was 87.80% (36/41) and 90.24% (37/41) respectively, with no significant difference between the two groups (χ2 = 0.12, P> 0.05) The incidence of adverse reactions in group B was 46.34% (19/41) and 19.51% (8/41) respectively after treatment. The difference between the two groups was statistically significant (χ2 = 6.68, P <0.05). After treatment, The levels of Ca, P, ALP, BAP and BMD in group A were (2.46 ± 0.09) mmoL / L, 1.47 ± 0.07 mmoL / L, 183.68 ± 26.54 U / L, 232.64 ± 17.02 and 2.24 ± 1.72, respectively. The indexes in group B were [(2.46 ± 0.08) mmoL / L], [(184.12 ± 24.83) U / L], [(233.52 ± 18.31)] and [(2.26 ± 1.86) ]Before and after treatment, there was no significant difference between each index (P> 0.05). Conclusion: Topiramate and levetiracetam have a good therapeutic effect on children with school-age epilepsy, but the incidence of adverse reactions is high and safety is low during the course of topiramate treatment. However, the short-term use of the two drugs on the bone metabolism No obvious effect.
李志毅. 托吡酯和左乙拉西坦对学龄期癫痫患儿骨代谢的影响[J]. 河北医学, 2018, 24(3): 408-411.
LI Zhiyi. Effects of Topiramate and Levetiracetam on Bone Metabolism in school-age Children with Epilepsy. HeBei Med, 2018, 24(3): 408-411.
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2018, Vol. 24 
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