Effect of Photodynamic Therapy Combined with Hormone Therapy on the Improvement of VSS Score and Expression of p-STAT3 and Egr-1 in Patients with Hypertrophic Scars
NING Jinbin, FENG Jian
Tangdu Hospital, Air Force Military Medical University, Shanxi Xi'an 710038, China
Abstract：Objective: To investigate the effect of photodynamic therapy combined with hormone therapy on the improvement of VSS score and the expression of p-STAT3 and Egr-1 in patients with hypertrophic scars. Method: A total of 124 patients with hypertrophic scars treated in our hospital from January 2014 to July 2016 were randomly divided into control group and observation group, with 62 patients in each group. The control group was treated with glucocorticoid alone. The observation group was treated with photodynamic therapy on the basis of the control group. The VSS score and the curative effect were evaluated and analyzed before and after treatment. The levels of p- STAT3, Egr-1 expression. Results: After 2 months of treatment, the VSS score of the observation group was significantly lower than that of the control group (P <0.05). The treatment efficiency of the observation group was significantly higher than that of the control group (P <0.05). After treatment, the levels of p-STAT3 and Egr-1 in both groups were significantly decreased (P <0.05), and the two indexes in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: The combined use of photodynamic therapy and glucocorticoid can effectively inhibit the expression of p-STAT3 and Egr-1 in patients with hypertrophic scar and reduce the score of VSS, which has better therapeutic effect and has certain safety.
宁金斌, 冯剑. 光动力法配合激素治疗对增生性瘢痕患者VSS评分改善效果及p-STAT3 Egr-1表达的影响[J]. 河北医学, 2018, 24(1): 135-139.
NING Jinbin, FENG Jian. Effect of Photodynamic Therapy Combined with Hormone Therapy on the Improvement of VSS Score and Expression of p-STAT3 and Egr-1 in Patients with Hypertrophic Scars. HeBei Med, 2018, 24(1): 135-139.
[1] Arno AI,Gauglitz GG,Barret JP,et al.Up-to-date approach to manage keloids and hypertrophic scars:A useful guide[J].Burns,2014,40(7):1255~1266. [2] Gauglitz GG,Korting HC,Pavicic T,et al.Hypertrophic scarring and keloids:pathomechanisms and current and emerging treatment strategies[J].moL Med,2011,17(1~2):113~125. [3] 李科,张铮,沃雁,等.光动力治疗瘢痕组织进展[J].中华全科医师杂志,2015,14(1):73~76. [4] Wang Q,Dong Y,Geng S,et a1.Photodynamic therapy inhibitsthe formation ofhypertrophic scars in rabbit ears by regulatingmetallopmteinases and tissue inhibitor of metalloproteinase-1[J].ClinExpDermatol,2014,9(2):196~201. [5] Li Z,Jin Z.Comparative effect and safety of verapamil in keloid and hypertrophic scar treatment:a meta-analysis[J].The rClin Risk Manag,2016,12(16):1635~1641. [6] Wang X,Qian Y,Jin R,et al.Effects of TRAP-1-Like Protein(TLP)Gene on Collagen Synthesis Induced by TGF-β/Smad Signaling in Human Dermal Fibroblasts.Goumans[J].PLoS ONE,2013,8(2):e55899. [7] 蔡景龙.现代瘢痕学[M].北京:人民卫生出版社,2008.332~334,724. [8] Sullivan T,Smith J,Kermode J,et a1.Rating the burn scar[J].Burn Care Rehabil,1990,11(3):256~260 [9] Martfnez-Caselles A,Pons-Minano JA,Vargas-Acosta A,et a1.Hepatoportal sclerosis clinical different evolutionary stages:presentation of 3 cases and literature review[J].Rev EspEnferm Dig,2012,104(2):94~97 [10] Din S,Thomas G,Morris J,et a1.Photodynamic therapy:an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools[J].Arch Dermatol Res,2013,305(3):205~214. [11] Ma X,Chen R,Hu X,et a1.Effects of matrine on JAK-STAT signaling transduction pathways in bleomycin induced pulmonary fibrosis[J].Aft Tradit Complement Ahem Med,2013,10(3):442~448. [12] Ud—Din S,Thomas G,Morris J,et a1.Photodynamic therapy:an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools[J].Arch Dermatol Res,2013,305(3):205~214. [13] Mair M,Blaas L,Osterreicher CH,et a1.JAK-STAT signalin in hepatic fibrosis[J].Front Biosci,2011,11(16):2794~2811. [14] 陈子翔,殷国前,潘新元,等.Egr-1、Nab2和Cav-1的表达与瘢痕增生的相关性研究[J].中华整形外科杂志,2016,32(6):453~457.
2018, Vol. 24 
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