Abstract:Objective: To investigate the clinical diagnosis and treatment of childhood mycoplasma pneumoniae infections with lung consolidation. Methods: Clinical data and treatment of 149 children mycoplasma pneumoniae infections with lung consolidation hospitalized were analyzed retrospectively. Results: (1) All the 149 patients had fever and cough. The average course of disease before admission was 10.7±6.0 days. The average course of disease after admission was 3.87±4.57 days and the average stay was 15.9±6.5 days. Among the 149 children, there were 105 cases with hyperpyrexia; White blood cell (WBC) was normal in 87 cases; Unilateral lung involvement was found in 131 cases; there were 70 cases with Pleural effusion and 5 cases with pulmonary necrosis; And there were 58 preschool children and 75 school-age children, no significant difference was found in sex, maximum body temperature, length of stay, fever duration and complications between the two groups. (2) For the treatment, azithromycin was the first drug and sensitive antibiotics was used if complicated with bacterial infection. And bronchoalveolar Lavage with bronchoscope was indispensable. Moreover, short-period application of glucocorticosteroid on critical patients can effectively improve clinical symptoms. Conclusions: Childhood mycoplasma pneumoniae infections with lung consolidation can occur at all ages and more common at preschool and school age. Its incidence of RMPP is high. White blood cell was normal and Unilateral lung involvement was found in most patients. It was relatively serious and had prolonged course,however,it can be clinically cured with combined modality treatment mostly.