Abstract：Objective: To determin the expression of HGF and its receptor c-met in human esophageal carcinoma and to investigate the relationship between HGF and its receptor with lymphangiogenesis and lymphatic metastasis of EC. Method: Immunohistochemical staining was used to examine expression of HGF and c-met in 30 cases of NM and 70 cases of EC tissues.The microlymphatic density (LMVD) in esophageal carcinoma was calculated by D2-40 as the specific marker of lymphatic endothelium. Results: Expression of HGF and c-met in EC showed significantly higher than that in NM, and they were positively correlated with lymphangiogenesis and lymphatic metastasis of EC. Conclusion: The overexpression of HGF and c-met may play an important role in lymphangiogenesis and lymphatic metastasis of EC.
赵杨, 刘莎莎, 徐树雷, 申兴斌. 食管癌中肝细胞生长因子及其受体的表达与淋巴管生成和淋巴结转移的关系[J]. 河北医学, 2018, 24(1): 26-30.
ZHAO Yang, LIU Shasha, et al. The Expression of HGF and its Receptor c-met in Human Esophageal Carcinomaand the Relationship to Lymphangiogenesis and Lymphatic Metastasis of EC. HeBei Med, 2018, 24(1): 26-30.
[1] 谷光福,朱正秋.MACC1、HGF、c-Met蛋白在胃癌组织中的表达及意义[J].胃肠病学和肝病学杂志,2016,(11):1229~1232. [2] Sun R, Zhang Q, Guo L, et al. HGF stimulates proliferation through the HGF/c-met pathway in nasopharyngeal carcinomacells[J].Oncol Lett,2012,3(5):1124~1128. [3] Cao R, Bjomdahl MA, Gallego MI, et al. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action[J].Blood,2006,107 (9):3531~3536. [4] Saito S, Morishima K, Ui T, et al.The role of HGF/MET and FGF/FGFR in fibroblastderived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma[J].BMC Cancer,2015,15:82. [5] Ren Y, Cao B, Law S, et al. Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic maker of human esophageal squamous cell carcinomas[J].Clin Cancer Res,2005,11(17): 6190~6197. [6] Goyal L, Muzumdar MD, Zhu AX.Targeting the HGF/c-MET pathway in hepatocellular carcinoma[J].Clin Cancer Res,2013,19( 9):2310~2318. [7] Kajiya K, Hirakawa S, Ma B, et al. Hepatocyte growth factor promoteslymphatic vessel formation and function[J].EMBO,2005,24(16):2885~2895. [8] Cao R, Bjomdahl MA, Gallego MI, et al. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action[J].Blood,2006,107(9):3531~3536.
2018, Vol. 24 
冀公网安备13080202000677号