Abstract：Objective: To analyze the infection current status and drug resistance of multiple drug resistant organism (MDRO) in a grade A tertiary hospital from 2014 to 2016. Methods: Samples of urine, sputum, blood and secretions were collected from hospitalized patients of a grade A tertiary hospital from 2014 to 2016, and their multi-drug resistant strains were isolated and the susceptibility test was given. Results: There were 2365 strains of MDRO, 1002 strains (42.37%) of sputum, 484 strains (20.47%) of urine, 295 strains (12.47%) of secretions and 250 strains (10.57%) of blood among 53364 examined samples. There were 805 strains (34.04%) in 2014, 750 strains (31.71%) in 2015 and 810 strains (34.25%) in 2016. And there were mainly ECO with 1323 strains (55.94%). The distribution rate of MDRO was the highest in ICU ward and 453 strains (19.15%) were detected. Staphylococcus aureus was highly resistant to penicillin, oxacillin and ampicillin and was sensitive to vancomycin, teicoplanin and linezolid. Escherichia coli was highly resistant to ampicillin, ciprofloxacin and levofloxacin and was sensitive to the imipenem, amikacin and piperacillin/tazobactam. Klebsiella pneumoniae was highly resistant to ciprofloxacin and cotrimoxazole and was sensitive to imipenem and piperacillin/tazobactam. Acinetobacter baumannii was highly resistant to the ceftriaxone, ciprofloxacin and imipenem. Pseudomonas aeruginosa was highly resistant to the cefuroxime and ceftriaxone and was more sensitive to ampicillin. Conclusions: The MDRO detection rate is higher in the hospital, and we should strictly control the clinical abuse of antimicrobial drugs in departments, and strengthen the monitoring of MDRO.
赵怡鸿, 曲海, 马媛, 赵云, 李艳. 2014年至2016年某三级甲等医院多重耐药菌感染现状及耐药性分析[J]. 河北医学, 2018, 24(6): 1048-1051.
ZHAO Yihong, QU Hai, MA Yuan, et al. Status and Drug Resistance of Multidrug-resistant Bacteria in a Three Grade A Hospital from 2014 to 2016. HeBei Med, 2018, 24(6): 1048-1051.
2018, Vol. 24 
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