沙丁胺醇布地奈德雾化吸入对毛细支气管炎患儿肺功能的影响

doi:10.3969/j.issn.1006-6233.2018.06.038

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摘要 目的:探讨沙丁胺醇、布地奈德雾化吸入对毛细支气管炎患儿肺功能的影响。方法:选择2013年11月至2016年11月住院治疗的毛细支气管炎患儿220例,采用随机数字表法,分为观察组和对照组,每组110例。比较分析两组患儿治疗后的临床指标、临床肺功能、疗效改善情况。结果:治疗后,观察组喘气急缓解、咳嗽消失、肺部啰音消失及住院时间,与对照组比较,均有显著性差异(P<0.05)。治疗前,两组患儿肺功能指标检测无显著性差异(P>0.05)。治疗后,观察组Ti/Te(%)、VPEF/VE(%)、TPTEF/TE(%)、Vt /kg(mL/kg)四项指标,较对照组均显著提高,具有显著性差异(P<0.05)。观察组与对照组治疗后,显效分别为(30.91%VS21.82%);有效分别为(56.36%VS 50.00%);无效率分别为(12.73%VS 28.18%);总有效率分别为(87.27%VS 71.82%),两者比较差异有统计学意义(χ²=10.208,P=0.013)。7d的治疗期间,两组患儿均未出现不良反应,治疗后肝肾功能,血尿常规等均正常。结论:3%高渗盐水雾化联合沙丁胺醇、布地奈德雾化吸入治疗毛细支气管炎疗效确切,显著改善患儿肺功能,安全性较好。

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关键词 ：毛细支气管炎, 沙丁胺醇, 布地奈德, 肺功能

Abstract：Objective: To investigate the effects of atomization inhalation of salbutamol and budesonide on pulmonary function in children with bronchiolitis. Methods: A total of 220 children with bronchiolitis hospitalized in two families of Langfang People's Hospital from November 2013 to November 2016 were selected and divided into the observation group and the control group, with 110 cases in each group. The clinical indicators, clinical pulmonary function and curative effect of the two groups were compared. Results: After treatment, the observation group was relieved of asthma, cough disappeared, lung rale disappeared and hospitalization time, compared with the control group, there were significant differences (P<0.05). Before treatment, there was no significant difference in pulmonary function between the two groups (P > 0.05).After treatment, the Ti /Te(%)、VPEF /VE(%)、TPTEF /TE(%)、Vt /kg(ml/kg) in the observation group was significantly increased with the control group (P<0.05). After treatment in the observation group and the control group, the remarkable effect was (30.91%VS 21.82%); the effective was (56.36%VS 50.00%); the invalid was (12.73%VS 28.18%); the total effective rate was (87.27%VS 71.82%), there was significant difference(χ²=10.208,P=0.013). No adverse reaction was found in all two groups. The liver and kidney function and routine hematuria were normal after treatment. Conclusion: 3% hypertonic saline atomization combined with salbutamol and budesonide is effective in the treatment of bronchiolitis, significantly improving the lung function of the children, and the safety is better.

Key words： Bronchiolitis Albuterol Budesonide Lung function

基金资助:廊坊市科技计划项目,(编号:2016013177)

引用本文:

于冬辉, 刘颖辉, 李永红, 于丽英. 沙丁胺醇布地奈德雾化吸入对毛细支气管炎患儿肺功能的影响[J]. 河北医学, 2018, 24(6): 1025-1027.
YU Donghui, LIU Yinghui, et al. Effects of Nebulization Inhalation of Salbutamol and Budesonide on Pulmonary Function in Children with Bronchiolitis. HeBei Med, 2018, 24(6): 1025-1027.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.06.038 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I6/1025