Effect of Sequential Therapy with Azithromycin Combined Shuanghuanglian Oral Liquid on the T Lymphocyte Subsets, Serum Inflammatory Cytokines Levels of Children with Mycoplasma Pneumonia
WANG Meng, ZHANG Xiuqin, YANG Jing, et al
Shaanxi Second People's Hospital, Shaanxi Xi'an 710005, China
Abstract：Objective: To explore the effect of sequential therapy with azithromycin combined with shuanghuanglian oral liquid on the T lymphocyte subsets, serum interleukin-6 (IL-6), tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hs-CRP) levels of children with mycoplasma pneumonia. Methods: 172 cases of children with mycoplasma pneumonia in our hospital from March 2015 to December 2016 were selected. According to simple random method, all the patients were divided into two groups with 86 cases in each group. Sequential therapy with azithromycin were given to both groups and shuanghuanglian oral liquid was given to the observation group additionally. The clinical effect, T lymphocyte subsets, serum IL-6, TNF-α and hs-CRP levels before and after treatment were compared between two groups. Results: The total effective rate of observation group was 96.51%, which was significantly higher than that of the control group (88.37%) (P<0.05). The T lymphocyte subsets CD3+, CD4+ ratio, CD4+/CD8+ of both groups of children after treatment were significantly higher than those before treatment(P<0.01), the CD8+, serum IL-6, TNF-α and hs-CRP levels were significantly lower than those before treatment, and the improvement of the indicators mentioned above in the observation group were more obvious than those of the control group. Between groups, statistically significant at different times within the group (P<0.01). No significant difference was found in the incidence of adverse reactions between two groupsP>0.05). Conclusion: Azithromycin sequential therapy combined with Shuanghuanglian oral liquid could effectively improve the immune function, reduce inflammatory response with high safety for the children with mycoplasma pneumonia.
王盟, 张秀芹, 杨静, 林文娟, 林文静. 阿奇霉素序贯疗法联合双黄连口服液对支原体肺炎患儿T淋巴细胞亚群及血清炎症因子水平的影响[J]. 河北医学, 2018, 24(6): 1013-1016.
WANG Meng, ZHANG Xiuqin, YANG Jing, et al. Effect of Sequential Therapy with Azithromycin Combined Shuanghuanglian Oral Liquid on the T Lymphocyte Subsets, Serum Inflammatory Cytokines Levels of Children with Mycoplasma Pneumonia. HeBei Med, 2018, 24(6): 1013-1016.
2018, Vol. 24 
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