摘要目的:探讨复方玄驹胶囊治疗慢性前列腺炎患者的临床疗效以及对血清巨噬细胞炎性蛋白-2(MIP-2)、分泌型免疫球蛋白(SIgA)水平的影响。方法:选择2014年9月至2016年3月在我院接受治疗的130例慢性前列腺炎患者,按随机数字表发分为观察组和对照组,每组各65例。对照组每日服用1片盐酸莫西沙星片,同时进行1次前列腺按摩;观察组在此基础上加服复方玄驹胶囊,每日三次,每次三粒。对比两组患者的疗效及治疗前后血清MIP-2和SIgA水平的变化。结果:观察组患者的总有效率显著高于对照组,治疗后的NIH-CPSI评分明显低于对照组(10.93±3.20) vs (19.68±4.27)(P<0.05);两组患者治疗后血清MIP-2和SIgA水平均显著低于治疗前,观察组患者的血清MIP-2和SIgA水平均低于对照组(4.17±0.61)ng/mL vs (6.20±1.04)ng/mL;(66.51±40.16)μg/mL vs (91.57±48.06)μg/mL(P<0.05);两组患者治疗后的前列腺白细胞分泌量均显著下降,且观察组患者分泌量的显著低于对照组(15.38±11.39)个/HP vs (21.74±10.59)个/HP (P<0.05)。结论:复方玄驹胶囊治疗可显著提高慢性前列腺炎患者的临床效果,促进病情恢复并且有效降低血清MIP-2和SIgA的表达。
Abstract：Objective: To investigate the clinical efficacy of compound Xuanju capsule in the treatment of chronic prostatitis and the influence on the serum MIP-2 and SIgA levels. Methods: 130 cases of patients with chronic prostatitis treated from September 2014 to March 2016 in our hospital were selected and divided into the observation group and the control group according to the random number table, with 65 cases in each group. The control group was given a daily moxifloxacin hydrochloride tablets and prostate massage once; the observation group was given complex Xuanju capsules on the basis of control group, three times a day, three tablets each time. The changes of serum MIP-2 and SIgA levels were compared between the two groups before and after treatment. Results: The overall effective rate was significantly higher in the observation group than that in the control group, and the NIH-CPSI score after treatment was significantly lower than that of the control group [(10.93±3.20) vs (19.68±4.27)](P<0.05). The levels of serum MIP-2 and SIgA in both groups were significantly lower than those in the control group before and after treatment, the serum MIP-2 and SIgA levels in the observation group were lower than those in the control group [(4.17±0.61)ng/mL vs (6.20±1.04) ng/mL];[(66.51±40.16) μg/mL vs (91.57±48.06)μg/mL] (P<0.05). The secretion of white blood cells in the two groups was significantly decreased after treatment, and the secretion of the observation group was significantly lower than that of the control group [(15.38±11.39)n/HP vs(21.74±10.59)n/HP] (P<0.05). Conclusion: Compound Xuanju capsule could significantly improve the clinical effect of chronic prostatitis patients, which could promote the recovery of the disease and effectively reduce the expressions of serum MIP-2 and SIgA.
万涛, 周治军, 卢童, 龚化, 杨为民, 徐康. 复方玄驹胶囊治疗慢性前列腺炎的临床疗效及对血清MIP-2 SIgA水平的影响[J]. 河北医学, 2018, 24(6): 894-897.
WAN Tao, ZHOU Zhijun, LU Tong, et al. Clinical Efficacy of Compound Xuanju Capsule in Treatment of Chronic Prostatitis and the Influence on Serum MIP-2 and SIgA Levels. HeBei Med, 2018, 24(6): 894-897.
2018, Vol. 24 
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