Abstract：Objective: To investigate the expression of multidrug resistance associated protein 1 (MRP1) in osteosarcoma and its relationship with pathological features of osteosarcoma. Methods: 80 cases of osteosarcoma admitted to our hospital from January 2016 to January 2017 were selected as the research group. Meanwhile, 20 healthy persons in the same period were selected as control group. The difference between MRP1 in the two groups was compared, and the relationship between MRP1 and tumor stage and tumor size was analyzed. Results: The positive rate and positive rate of MDR1 in osteosarcoma patients were significantly higher than those in normal bone tissue (P<0.05). The positive expression of MDR1 and P-gP in grade III patients and grade IV patients were significantly higher than those in grade I and grade II patients (P < 0.05). The positive rate of MDR1 and P-gP expression in large tumor patients and the positive rate were significantly lower than those in patients with small tumors (P < 0.05). Conclusion: The expression of MDR1 is positively related to the pathological grade of osteosarcoma patients, and there is a negative correlation with the size of the tumor. It is necessary for the medical staff to pay attention to the clinical treatment.
李战鹏. 多药耐药相关蛋白1在骨肉瘤中的表达及同患者病理特征关系的分析[J]. 河北医学, 2018, 24(6): 890-893.
LI Zhanpeng. Expression of Multidrug Resistance Associated Protein 1 in Osteosarcoma and the Relationship with Pathological Characteristics. HeBei Med, 2018, 24(6): 890-893.
[1] 丰涛,沈赞.三氧化二砷对骨肉瘤细胞株MG63/dox多药耐药的逆转作用及其机制[J].临床肿瘤学杂志,2016,21(1):6~11. [2] 陈自强,张玮,李玉平,等.纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展[J].药学实践杂志,2016,34(2):103~105. [3] Egorov D, Schwob L, Lalande M, et al. Near edge X-ray absorption mass spectrometry of gas phase proteins: the influence of protein size[J]. Physical Chemistry Chemical Physics Pccp, 2016, 18(37):26213. [4] 郑铁钢,郭全义,陈继营,等.载多柔比星磁性纳米颗粒逆转人骨肉瘤细胞多药耐药性的实验研究[J].肿瘤研究与临床,2015,27(6):361~364. [5] 李梦双,郭传龙,李君,等.多药耐药蛋白1和多药耐药相关蛋白5、7在糖尿病小鼠视网膜中表达的变化[J].眼科新进展,2017,37(1):10~14. [6] Schennach M, Breuker K. Probing protein structure and folding in the gas phase by electron capture dissociation[J]. Journal of The American Society for Mass Spectrometry, 2015, 26(7):1059~1067. [7] 孙振国,张治宇,王锋.骨肉瘤耐药性相关信号转导通路研究进展[J].医学综述,2017,23(3):488~491. [8] van Zweeden A A, Hj V D V, Wilmink J W, et al. Phase I clinical trial to determine the feasibility and maximum tolerated dose of panitumumab to standard gemcitabine-based chemoradiation in locally advanced pancreatic cancer.[J]. Clinical Cancer Research,2015, 21(20):4569. [9] 陈楷,吕书军,付东,等.骨肉瘤凋亡与耐药相关机制的研究进展[J].中国骨与关节杂志,2015,2(1):45~49. [10] 符策岗,赵红卫,刘扬,等.骨肉瘤直接抑制化疗药物疗效的分子机制[J].海南医学,2015,3(1):70~73. [11] Evens A M, Balasubramanian S, Vose J M, et al. A phase I/II multicenter, open-label study of the oral histone deacetylase inhibitor abexinostat in relapsed/refractory lymphoma.[J]. Clinical Cancer Research, 2016, 22(5):1059. [12] 张浩强,王臻,鲍莉,等.拷贝数变异对多发骨肉瘤临床分型与耐药机制的影响[J].中华骨科杂志,2015,35(4):442~449. [13] 吴宏增,王进,冯和林.自噬与骨肉瘤的研究进展[J].肿瘤防治研究,2017,44(2):153~156. [14] 尤龙飞,丁木亮,倪江东.lncRNA在骨肉瘤中的研究进展[J].医学临床研究,2016,33(10):1993~1997. [15] 侯晓,李纯璞,陈元振,等.Notch通路在骨肉瘤发病机制中的研究现状[J].中国矫形外科杂志,2015,23(9):804~807.
2018, Vol. 24 
冀公网安备13080202000786号