Abstract：Objective: To explore the correlation between serum metal ions, vitamin B12 and the pathogenesis of Alzheimer’s disease (AD). Methods: Forty-six patients who met AD diagnostic criteria were selected as AD group, and Forty-five elderly patients with normal cognitive function at the same time were selected as control group. The contents of Cu, Zn, Fe, Pb, Cd, Ca, Mg and Mn in the two groups were compared. Logistic regression analysis was used to analyze the correlation between 8 kinds of metal ions, vitamin B12 and simple intelligent state scale (MMSE) score. Results: The concentration of copper ion in AD group was significantly higher than that in control group; Vitamin B12 content was significantly lower than the control group, the difference was statistically significant (t = 3.477,5.102, all P <0.05). Logistic regression analysis showed that both copper ion, vitamin B12 content and age all contributed to the independent risk factors of MMSE score decline in AD patients (χ2= -0.256, 4.527, -0.328, all P <0.05). Conclusion: The levels of copper ion and vitamin B12 in elderly patients are related to AD, which are independent risk factors of AD.
宋磊, 李华, 付毅敏. 血清金属离子维生素B12浓度与阿尔茨海默病相关性研究[J]. 河北医学, 2018, 24(5): 809-811.
SONG Lei, LI Hua, FU Yimin. Relationship between Serum Metal Ions, Vitamin B12 and Alzheimer Disease. HeBei Med, 2018, 24(5): 809-811.
[1] Fiest K M, Jetté N, Roberts J I, et al. The Prevalence and Incidence of Dementia: a Systematic Review and Meta-analysis.[J]. Canad J Neurolog Sci Le Canad Des Sci Neurolog, 2016, 43 Suppl 1(S1):S3~S50. [2] 郑芳芳,陈士华,闻传毅,等.多奈哌齐联合叶酸、维生素B12治疗对老年阿尔茨海默病伴高同型半胱胺酸血症患者血清炎性因子、HCY、NSE及脑神经递质的影响[J].海南医学院学报,2017,23(16):2274~2277. [3] Kulikova A A, Makarov A A, Kozin S A. Roles of zinc ions and structural polymorphism of β-amyloid in the development of Alzheimer’s disease[J]. Mol Biol, 2015, 49(2):217~230. [4] Hadzhieva M, Kirches E, Mawrin C. Review: iron metabolism and the role of iron in neurodegenerative disorders[J]. Neuropath App Neuro, 2014, 40(3):240~257. [5] Graham S F, Nasaruddin M B, Carey M, et al. Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies[J].Alzheimers Dis Jad, 2014, 42(4):1407~1413. [6] Ferreira M E S, Vasconcelos A S D, Vilhena T D C, et al. Oxidative stress in alzheimer's disease: should we keep trying antioxidant therapies [J]. Cell Molecu Neurobiol, 2015, 35(5):595~614. [7] Shilling D, Müller M, Takano H, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis[J].Neurosci, 2014, 34(20):6910~6923. [8] Squitti R, Siotto M, Polimanti R. Low-copper diet as a preventive strategy for Alzheimer's disease.[J]. Neurobiol Aging, 2014, 35(3):S40~S50. [9] Shankle W R, Hara J, Barrentine L W, et al. Cerefolin NAC therapy of hyperhomocysteinemia delays cortical and white matter atrophy in alzheimer's disease and cerebrovascular disease.[J].Alzheimers Dis Jad, 2016, 54(3):1073~1084. [10] Oulhaj A, Jernerén F, Refsum H, et al. Omega-3 fatty acid status enhances the prevention of cognitive decline by B vitamins in mild cognitive impairment[J].Alzheimers Dis, 2016, 50(2):547~557. [11] Prasher V P, Prasher M. Folate, vitamin B(12), Down syndrome and alzheimer's disease[J]. Int Geriatr Psychiatry, 2016, 31(12):1372~1373. [12] 胡尧,郭启浩,岑屹,等.老年痴呆患者认知功能与维生素B_(12)及叶酸的相关性[J].检验医学,2017,32(4):284~289.
2018, Vol. 24 
冀公网安备13080202000677号