Abstract：Objective: To investigate the effects of simvastatin combined coenzymeQ10 on ventricular remodeling and cardiac function in rats with chronic heart failure (CHF). Methods: 40 SD rats were randomly divided into five groups:sham-operated group,coenzymeQ10 group,simvastatin group,simvastatin combined coenzymeQ10 group and model group.Coarctation of abdominal aorta (CCA) except for the shame-operated group. Testing hemodynamic of left ventricular end-diastolic diameter press (LVEDP),left ventricular pressure rise and fall (±dp/dtmax),left ventricular mass/body mass (LVMI);HE and Masson’s trichrome staining for morphology. Results: Compared with model group, hemodynamic analysis revealed that left ventricular end-diastolic pressure (LVEDP) were significantly lower in simvastatin group, coenzymeQ10, simvastatin combined coenzymeQ10 group(P<0.01), left ventricular pressure rise and fall increased remarkable(P<0.01);In addition, left ventricular mass/body mass (LVMI) and collagen volume fraction(CVF%) was decreased sharply(P<0.01).CoenzymeQ10 group,simvastatin combined coenzymeQ10 groups improved CHF remarkable than rest groups (P< 0.05).Conclusion: All of these results verify that treatment with simvastatin combined coenzymeQ10 has more obvious effects on improving heart function of rats with cardiac remodeling and inhibit ventricular remodeling.
于海荣, 张秀芝, 王济兴, 吕博杰, 陈建双. 辛伐他汀联合辅酶Q10对慢性心衰大鼠心功能及心室重构的影响[J]. 河北医学, 2016, 22(10): 1615-1617.
YU Hairong, et al. Effects of Simvastatin Combined CoenzymeQ10 on Ventricular Remodeling and Cardiac Function in Rats with CHF. 河北医学, 2016, 22(10): 1615-1617.
2016, Vol. 22 
冀公网安备13080202000786号