中性粒细胞淋巴细胞比例在预测甲状腺乳头状癌术后侧颈部淋巴结复发的价值

doi:10.3969/j.issn.1006-6233.2017.09.009

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摘要 目的: 探讨甲状腺乳头状癌(PTC)患者术前中性粒细胞淋巴细胞比例(NLR)与术后侧颈部淋巴结复发的关系。方法: 回顾性的纳入我院2012年8月至2016年12月入住我科的PTC患者血常规标及术后复发情况。分析术前的NLR比例与术后侧颈部淋巴结转移的关系。结果: 总共211例病人纳入此次分析,其中有50(23.7%)例患者术后出现侧颈部淋巴结的转移。术前外周血NLR高于2.6是PTC患者术后侧颈部淋巴结复发的独立危险因素。结论: 高NLR是PTC术后侧颈部淋巴结转移的高危影响因素。NLR高于2.6的病人术后复诊过程中需要常规检查侧颈部淋巴结情况。

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	郑绪才
	王圣应
	刘建军
	洪士开

关键词 ：甲状腺乳头状癌, 中性粒细胞淋巴细胞比例, 侧颈部淋巴结转移, 风险因素

Abstract：Objective: To investigate the relationship between preoperative neutrophil lymphocyte ratio (NLR) and cervical lymph node recurrence in patients with thyroid papillary carcinoma (PTC). Method: PTC Patients from our hospital in January 2009 to December 2014 were retrospective analyzed. The relationship between those patients&apos|serum routine markers and postoperative recurrence were analyzed by Cox analysis. Results: A total of 211 patients were included in the analysis, of which 50 (23.7%) patients had postoperative cervical lymph node metastasis. Preoperative peripheral blood NLR higher than 2.6 is an independent risk factor for postoperative cervical lymph node recurrence in PTC patients. Conclusion: Higher NLR is a high risk factor for lymph node metastasis after PTC. NLR higher than 2.6 patients in the process of follow-up routine examination of cervical lymph nodes.

Key words： Thyroid papillary carcinoma Neutrophil lymphocyte ratio Lateral neck lymph node metastasis Risk factor

基金资助:安徽省高校省级自然科学研究项目,(编号:KJ2013Z142)

引用本文:

郑绪才, 王圣应, 刘建军, 洪士开. 中性粒细胞淋巴细胞比例在预测甲状腺乳头状癌术后侧颈部淋巴结复发的价值[J]. 河北医学, 2017, 23(9): 1437-1439.
ZHENG Xucai, WANG Shengying, LIU Jianjun, et al. The Value of Neutrophil Lymphocyte Ratio in Predicting Recurrence of Postoperative Cervical Lymph Node Metastatic in Papillary Thyroid Carcinoma. 河北医学, 2017, 23(9): 1437-1439.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2017.09.009 或 http://www.hbyxzzs.cn/CN/Y2017/V23/I9/1437

[1] Desantis CE, Lin CC, Mariotto AB, et al.Cancer treatment and survivorship statistics, 2014[J].Cancer Clin, 2014, 64(4):252~271.
[2] Lang B, Lo CY, Chan WF, et al.Restaging of differentiated thyroid carcinoma by the sixth edition AJCC/UICC TNM staging system: stage migration and predictability[J].Ann Surg Oncol, 2007, 14(5):1551~1559.
[3] Pacini F, Elisei R, Capezzone M, et al.Contralateral papillary thyroid cancer is frequent at completion thyroidectomy with no difference in low- and high-risk patients[J].Thyroid, 2001, 11(9):877~881.
[4] Duntas L, Grab-Duntas BM. Risk and prognostic factors for differentiated thyroid cancer[J].Hell Nucl Med, 2006, 9(3):156~162.
[5] Coussens LM, Werb Z. Inflammation and cancer[J].Nature, 2002, 420(6917):860~867.
[6] Davis BK, Wen H, Ting JP. The inflammasome NLRs in immunity, inflammation and associated diseases[J].Annu Rev Immunol, 2011, 29:707~735.
[7] 朱亮,姚寒晖,吴杨. 胃癌患者术前外周血中性粒细胞和淋巴细胞比值与术后病理的相关性分析[J]. 安徽医学, 2016,37(12):1547~1549.
[8] 孟泽,李培勇,严佶祺,等. 乳头状甲状腺癌患者中性粒细胞和淋巴细胞比值与肿瘤特征的关系[J]. 安徽医药, 2014(10):1880~1884.
[9] Seretis C, Gourgiotis S, Gemenetzis G, et al.The significance of neutrophil/lymphocyte ratio as a possible marker of underlying papillary microcarcinomas in thyroidal goiters: a pilot study[J].Am J Surg, 2013, 205(6):691~696.
[10] Liu CL, Lee JJ, Liu TP, et al.Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer[J].Surg Oncol, 2013, 107(5):493~497.
[11] Lee KH, Lee CH, Jeong J, et al.Neutrophil elastase differentially regulates interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) production by cigarette smoke extract[J].Biol Chem, 2015, 290(47):28438~28445.
[12] Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer[J].Intern Med, 2000, 248(3):171~183.