Abstract：Objective: To study the clinical effect of trimetazidine in treatment of chronic heart failure and its effect on cardiac function and high sensitivity c-reactive protein. Methods: 94 patients with chronic heart failure from August 2015 to October 2017 in our hospital were selected, according to random table method, those patients were divided into control group (n=47)and research group (n=47). control group were treated with routine therapy. research group were treated with trimetazidine based on the control group. Then clinical treatment effect, Left ventricular ejection fraction (LV), left ventricular ejection fraction (LVEF), cardiac function classification, serum interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α),hs-CRP and acute cardiac events between two group was compared. Results: After treatment, the effective rate of research group was significantly higher than the control group 95.74% vs 80.85%, there was statistically significant (P<0.05).the FS and LVEF in two group was up, the research group was higher than the control group, and LVEDD and NYHA in two group were decreased, and the decrease was more obvious in the research group, there was statistically significant (P<0.05). IL-6, TNF-α,hs-CRP in the two groups decreased, and the research group was lower than the control group (P<0.05). There were thrombosis and arrhythmia in both groups, but the rate of the research group was lower than the control group, and there was a difference between the groups (P< 0.05). Conclusion: Application of trimetazidine in the treatment of chronic heart failure can effectively reduce serum high-sensitivity C-reactive protein levels, improve their cardiac function, improve the clinical efficacy of comprehensive treatment.
程德均. 曲美他嗪治疗慢性心力衰竭的临床研究及对心功能与超敏C-反应蛋白的影响[J]. 河北医学, 2018, 24(4): 619-622.
CHENG Dejun. Clinical Study of Trimetazidine in Treatment of Chronic Heart Failure and Its Effect on Cardiac Function and High Sensitivity C-reactive Protein. HeBei Med, 2018, 24(4): 619-622.
[1] 李庆.中西医结合治疗老年慢性心力衰竭58例的效果分析[J].转化医学电子杂志,2015,2(5):123~124. [2] 宿宁,万新红,罗玉梅,等.心力衰竭治疗研究进展[J].医学综述,2017,23(10):1954~1957. [3] 邵波,王炳银,陈润祥,等.曲美他嗪对冠心病慢性心力衰竭患者心功能及心率震荡的影响[J].中国康复理论与实践,2014,11(4):382~384. [4] 毛治尉,李巧玲,王平,等.曲美他嗪对慢性心力衰竭患者心功能和血清MMP-9、TIMP-1的影响[J].中国老年学杂志,2015,32(10):2817~2819. [5] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会.慢性心力衰竭诊断治疗指南[J].中华心血管病杂志,2007,35(12):1076. [6] 中华医学会心血管病分学会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98. [7] Lanza GA,Parrinello R, Figliozzi S. Cardiac syndrome X and microvascular angina[J].2014. [8] 洪飞,汪磊,HONGFei,等.慢性心力衰竭患者血清CA125、hs-CRP和TNF-α水平及其与心功能的关系[J].中国医科大学学报,2017,46(9):787~790. [9] 周全魁,胡菁.辛伐他汀联合曲美他嗪治疗老年慢性心力衰竭患者的疗效和安全性[J].中国老年学杂志,2015,31(8):2240~2241. [10] 荆爱玲.曲美他嗪治疗慢性心力衰竭的疗效及机制研究[J].现代预防医学,2012,39(20):5469~5470. [11] Amhrosy AP, Butler J, Ahmed A, et al. The use of digoxin in patients with worsening chronic heart failure:reconsidering an old drug to reduce hospital admissions[J]. Am Coll Cardiol,2014, 63 (18):1823~1832.
2018, Vol. 24 
冀公网安备13080202000677号