Abstract：Objective: To discuss effects of stellate ganglion block with aparoscopic gastrectomyon for gastric cancer on Serum Aβ-42、 IL-1β、TNF-α and brain oxygen metabolism in patients. Methods: A total of 98 patients who underwent radical gastrectomy from June 2015 to November 2017 were randomly divided into experimental group and control group (n = 49). The experimental group was treated with stellate nerve block and general anesthesia. The control group received normal saline combined with general anesthesia. The serum A beta -42, IL-1 beta, and TNF- alpha were compared between the two groups. Compared before anesthesia induction (T0), endotracheal intubation (T1), pneumoperitoneum establishment (T2), radical gastrectomy (T3) and recovery time after extubation (T4), cerebral oxygen supply and demand index was compared. The indexes of cerebral oxygen supply and demand were: internal jugular bulb oxygen saturation (SjvO2), internal jugular venous oxygen partial pressure (PjvO2), arterial oxygen saturation (SaO2), arterial oxygen partial pressure (PaO2), radial artery internal jugular bulb blood oxygen content difference (Da-jvO2) and cerebral oxygen uptake rate (CEO2) were compared. Results: After treatment, the levels of serum Aβ-42, IL-1β and TNF-α were increased in both groups (P<0.05). The levels of serum Aβ-42, IL-1β and TNF-α in the experimental group were significantly lower than those in the control group (P<0.05). The levels of SjvO2, PjvO2, SaO2 and PaO2 in the two groups were significantly lower than those in the control group (P<0.05). The levels of Da-jvO2 and CEO2 in the two groups were significantly higher than those before the operation (P<0.05), and the difference was significant (P<0.05). Conclusion: Laparoscopic radical gastrectomy for gastric carcinoma under stellate ganglion block can reduce the postoperative serum A beta -42, IL-1 beta, TNF- alpha and improve brain oxygen metabolism.
2018, Vol. 24 
冀公网安备13080202000677号