Abstract：Objective: To study the curative efficacy of huaier granule combined with neoadjuvant chemotherapy on the breast cancer and the serum levels of P53 gene(P53), Ki-67 antigen(Ki-67), matrix metalloproteinase (MMP)-2 and matrix metalloproteinase (MMP-9). Methods: 92 patients with breast cancer admitted in our hospital from March 2011 to March 2013 were selected and randomly divided into the observation group (n=46) and the control group (n=46). The patients in control group were treated with neoadjuvant chemotherapy (pirarubicin+paclitaxel intravenous injection), while the patients in observation group were treated with huaier granule. Then the positive expression rate of P53 and Ki-67, changes of MMP-2 and MMP-9, clinical efficacy, survival rate and complications in the two groups were observed and compared before and after treatment. Results: After treatment, the positive expression rate of P53 in the observation group was significantly increased, and the positive rate of Ki-67 was significantly decreased (P<0.05), the serum levels of MMP-2 and MMP-9 of both groups were significantly lower than those before treatment and the MMP-2 and MMP-9 in the observation group were significantly lower than those of the control group (P<0.05). The clinical efficacy of observation group was significantly higher than that of the control group (P<0.05). The incidence rate of gastrointestinal reaction, myelosuppression, alopecia and liver function injury of observation group was significantly lower than that of the control group (P<0.05);during the follow-up period, 4 cases were lost in the observation group and 5 cases were lost in the control group,the survival rate in the observation group in 3 years was significantly higher than that of the control group. (P<0.05). Conclusion: Huaier granule combined with neoadjuvant chemotherapy had better clinical efficacy on breast cancer, which could effectively reduce the side effects and improve the prognosis, its may be closely related to the regulation of P53, Ki67, MMP-2, and MMP-9 levels.
单昌友, 刁岩, 黄珊, 贾丽君, 管海涛, 康华峰, 代志军, 张淑群. 槐耳颗粒联合新辅助化疗对乳腺癌的疗效及对P53 Ki-67 MMP-2 MMP-9水平的影响[J]. 河北医学, 2018, 24(4): 579-582.
SHAN Changyou, DIAO Yan, HUANG Shan, et al. Effect of Huaier Granule Combined with Neoadjuvant Chemotherapy for Breast Cancer and Its Influence on P53 Ki-67 MMP-2 and MMP-9 Levels. HeBei Med, 2018, 24(4): 579-582.
2018, Vol. 24 
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