Abstract：Objective: To observe the clinical curative effect of safflower injection combined with conventional rehabilitation therapy on hemodynamics and serum inflammatory factors in patients with cerebral infarction. Methods: 112 patients with cerebral infarction admitted in our hospital from September 2015 to May 2017 were divided into observation group and control group according to the random number table method. The control group was given routine rehabilitation treatment. On the basis of this, Combined with safflower injection treatment, each cycle included 28 days; compare the two groups of patients with clinical efficacy, hemodynamic changes, serum levels of inflammatory factors. Results: The total effective rate was 92.86% (52/56) in the observation group and 78.57% (44/56) in the control group. The difference was statistically significant (χ2 = 4.667, P<0.05).The scores of FMA and BI in the observation group were significantly higher than those in the control group, NIHSS score was significantly lower than the control group, the difference was statistically significant (P<0.05);After treatment, the high blood viscosity, low shear viscosity and plasma viscosity of the observation group were significantly lower than those of the control group. The maximal peak flow velocity and vascular resistance index of bilateral middle cerebral artery were significantly higher than those of the control group (P<0.05);The level of serum Hs-CRP in the observation group was significantly lower than that in the control group, and the levels of VEGF and TGF-β1 were significantly higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: On the basis of routine rehabilitation therapy, safflower injection can effectively improve the clinical efficacy of cerebral infarction patients, improve the blood flow status and reduce the level of serum inflammatory factors, which is worth to be spread.
王根强, 龙登毅, 贝宁, 贝筝, 焦宏伟. 红花注射液治疗脑梗死患者的临床疗效及对血清炎性因子的影响[J]. 河北医学, 2018, 24(4): 571-575.
WANG Genqiang, LONG Dengyi, BEI Nin, et al. The Effect of Safflower Injection in the Patients with Cerebral Infarction and Its Influence on Serum Inflammatory Factors. HeBei Med, 2018, 24(4): 571-575.
[1] 袁凤云,刘玉梅,孙科远,等.丹参多酚酸盐对脑梗死患者脑血流动力学的影响分析[J].中国煤炭工业医学杂志,2015,18(6):895~898. [2] 吴婧.丹红注射液联合康复锻炼针灸治疗对脑梗死患者脑血流动力学的影响及疗效[J].中国实用神经疾病杂志,2015,18(3):75~76. [3] Bonaventura A , Liberale L, Vecchié A , et al. Update on in-flammatory biomarkers and treatments in ischemic stroke[J]. Int Mol Sci,2016,17 (12):1967. [4] 马玉海.丹红注射液联合中医康复疗法治疗急性脑梗死45例[J].中国中医药,2014,12(11):38~39. [5] Arevalo-Lorido JC, Carretero-Gomez J, Fernandez-Recio JM, et al. Lowering C-reactive protein with statins after an is-chemic stroke avoids mortality and readmissions. A prospec-tive cohort study[J].Ann Med,2015,47(3): 226~232. [6] 张阿宁.hs-CRP、FIB 检测对脑梗死患者的意义[J].检验医学与临床, 2016,13(17): 2453~2454. [7] Chehaibi K ,Trabelsi I, Mahdouani K , et al. Correlation of ox-idative stress parameters and inflammatory markers in is-chemic stroke patients[J].Stroke Cerebrovasc Dis,2016, 25(11):2585~2593. [8] 吉 智,范秀博.注射用红花黄色素联合阿加曲班治疗急性脑梗死的临床研究[J].现代药物与临床,2016,31(2):158~162. [9] 魏艳霞.红花注射液联合康复治疗对老年脑梗死患者的临床疗效观察[J].中国临床药理学杂志,2016,32(7):585~587,590. [10] 路小薇.急性脑梗死患者血清炎性因子及血流动力学变化及意义[J].海南医学院学报,2016,22(1):93~95. [11] Kim J, Song T J, Song D, et al. Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction [J].Stroke,2013, 44(12):3547~3549. [12] Dwedar AZ, Ashour S, Haroun M, et al. Sonothrombolysis in acute middle cerebral artery stroke[J]. Neurol India,2014,62(1): 62~65. [13] 秦秀德,刘 玉,李传朋,等.红花注射液通过抗炎症反应治疗急性脑梗死的机制研究[J].中国中医急症,2017,26(3):409~411,459.
2018, Vol. 24 
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