Serum inflammatory Factors Vascular Endothelial Function and Pulmonary Function of Ulinastatin Combined with Ipratropium Bromide in the Treatment of AECOPD
LONG Shenghua, et al
The Central Hospital of Huangshi of Edong Medical Group, Hubei Huangshi 435000, China
Abstract：Objective: To observe the efficacy and effect on serum inflammatory factors, vascular endothelial function and pulmonary function of ulinastatin combined with ipratropium bromide in the treatment of AECOPD. Methods: 125 cases of patients with AECOPD were randomly divided into observation group (64 cases) and control group (61 cases).The control group were given ipratropium bromide based on conventional therapy,and the observation group were given ulinastatin based on the control group. After 1 week ,to observe the clinical efficacy and differences of serum inflammatory factors (hs-CRP, TNF-α, IL-1, IL-8), vascular endothelial function related indicators (ET-1, NO, TXB2, VEGF), and pulmonary function (TLC, PEF1, PEF25, PEF50) between the two group. Results: ①Comparison of curative efficacy the observation group, excellence got 32 cases, effective got 32 cases,invalid 4 cases failure,and those of the control group was 18 cases,37 cases and 6 cases. The clinical efficacy of the two groups showed significant difference(Z=-2.123 P=0.034); ②Comparison of serum inflammatory factors, and all indexs of the observation group improved more significantly than that of the control group, with statistical difference (t=5.419,5.184,4.893,7.241 P=0.000,0.002,0.006,0.000); ③Comparison of vascular endothelial function. The two groups of NO, VEGF were decreased and ET-1,TXB2 were decreased, and all indexs of the observation group improved more significantly than that of the control group, with statistical difference (t=9.182,18.831,6.271,11.382 P=0.000,0.000,0.000,0.000);④Comparison of vascular pulmonary function. The two groups of TLC, PEF1, PEF25, PEF50 were increased with before, and all the indexs of the observation group improved more significantly than that of the control group, with statistical difference (t=5.402, 4.927, 4.238, 5.701 P=0.009, 0.011, 0.019, 0.003). Conclusion: Ulinastatin combined with ipratropium bromide is effective in the treatment of AECOPD, which can effectively inhibit the inflammatory reaction, protect the vascular endothelial function and lung function.
龙升华, 张菁, 柯正华, 许伟, 黄丹. 乌司他丁联合异丙托溴铵治疗AECOPD的疗效及对血清炎症因子血管内皮功能肺功能的影响[J]. 河北医学, 2018, 24(4): 550-559.
LONG Shenghua, et al. Serum inflammatory Factors Vascular Endothelial Function and Pulmonary Function of Ulinastatin Combined with Ipratropium Bromide in the Treatment of AECOPD. HeBei Med, 2018, 24(4): 550-559.
2018, Vol. 24 
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