Abstract：Objective: To observe the expression of CK20, HIF-1α and PKM2 in colorectal cancer tissues. Methods: 73 cases of colorectal cancer tissue specimens in our hospital from December 2015 to December 2016 were selected as the research object (colorectal cancer group), and choose another 30 cases of normal colorectal tissue specimens as the control group. The expression of CK20, HIF-1α and PKM2 were detected by the immunohistochemical method. Results: In the colorectal cancer group, there was no significant differences of the expression rate of CK20, HIF-1α and PKM2 under different age, sex and differentiation degree(P>0.05), but the expression rate of different lymph node metastasis and Dukes stages of CK20, HIF-1α and PKM2 was statistically significant (P<0.05); In the colorectal cancer group, CK20 was positively related with HIF-1α (r=0.751, P<0.01); and PKM2 was positively related with HIF-1α, too (r=0.926, P<0.01)3. The expression of CK20, HIF-1α and PKM2 of the colorectal cancer group were significantly higher than those of the control group (P<0.05). Conclusion: The expression of CK20 and HIF-1α of the colorectal cancer tissue specimens are significantly higher than that of the colorectal normal tissue specimens, which showed certain prediction value on tumor value-added and metastasis for colorectal cancer patients.
彭微波, 韩林, 谭香. CK20 HIF-1α PKM2在结直肠癌组织中的表达[J]. 河北医学, 2018, 24(4): 529-531.
PENG Weibo, HAN Lin, et al. The Expression of CK20 HIF - 1α and PKM2 in Colorectal Cancer Tissues. HeBei Med, 2018, 24(4): 529-531.
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2018, Vol. 24 
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