Abstract:Objective: To analyze the curative effect of interventional cryotherapy for bronchial tuberculosis patients by fiberoptic bronchoscope. Methods: Sixty-eight patients with bronchial tuberculosis admitted to our hospital from October 2016 to October 2017 were randomly divided into control group and experimental group. Both groups were given routine anti-tuberculosis chemotherapy, while the experimental group was given fiberoptic bronchoscopic interventional cryotherapy on this basis. The sputum negative rate, chest CT changes and changes under bronchoscope were compared between the two groups. Results: There were 30 sputum positive patients, 4 sputum negative patients, 28 sputum positive patients and 6 sputum negative patients in the control group before treatment. After treatment, there were 14 sputum-positive patients, 20 sputum-negative patients, 9 sputum-positive patients and 25 sputum-negative patients in the control group, respectively. After treatment, the sputum negative rate of the experimental group was 89.29%, which was significantly higher than that of the control group 66.67% (χ2= 8.934, P<0.05). The total effective rate of the experimental group was 91.18%, which was significantly higher than that of the control group (χ2= 9.273, P<0.05). The total effective rate of fiberoptic bronchoscopy in the experimental group was 94.12%, which was significantly higher than 70.59% in the control group (χ2= 10.029, P<0.05). Conclusion: Transbronchoscopic cryotherapy combined with systemic chemotherapy can effectively improve the sputum negative rate of patients with bronchial tuberculosis, greatly improve the clinical efficacy of patients. It is worthy of clinical application.
[1] Hsiao CY, Huang KW. Irreversible electroporation: a novel ultrasound-guided modality for non-thermal tumor ablation[J]Med Ultrasound, 2017,25(4):195~200. . [2] Dhar A, Sikund K, Lall A, et al. Radiological spectrum of anthracofibrosis: a series of 40 patients with computed tomography, bronchoscopy, and biopsy[J]Indian Radiol Imaging, 2017,27(4):397~403. . [3] Awolude OA, Oyerinde SO, Akinyemi JO. Screen and triage by community extension workers to facilitate screen and treat: task-sharing strategy to achieve universal coverage for cervical cancer screening in nigeria[J]Glob Oncol, 2018,(4):1~10. . [4] Boo YL, How KN, Pereira DS, et al. Pulmonary actinomycosis masquerading as lung cancer: A case report[J]Med Malaysia, 2017,72(4):246~247. . [5] 石海萍,沈茂杨.支气管结核经支气管镜冷冻治疗疗效及对免疫功能的影响[J].河北医学,2016,22(12):1966~1968,1969. [6] Zhang J, Liu K, Elmadhoun O, et al. Synergistically induced hypothermia and enhanced neuroprotection by pharmacological and physical approaches in stroke[J]Aging Dis, 2018,9(4):578~589. . [7] Vlad D, Dutu A, Apostol A, et al. The effect of spray cryotherapy on microbial biofilms in chronic rhinosinusitis[J]Curr Infect Dis Rep, 2018,20(10):41. [8] Jeon KN, Ha JY, Park MJ, et al. Pulmonary tuberculosis in patients with emphysema: computed tomography findings[J]Comput Assist Tomogr, 2016,40(6):912~916. . [9] Ozyalvacli G, Yasar Z, Cetinkaya E. A cytopathological approach to diagnosing intrathoracic lymphadenopathy using aspirates obtained by the transbronchial needle aspiration method[J]Tuberk Toraks, 2016,64(1):53~59. [10] 孙扬,李文博,王月彩,等.氩等离子体凝固联合冷冻、局部注药治疗增殖型支气管结核疗效观察[J].现代中西医结合杂志,2018,27(3):270~272. [11] 石洁,朱岩昆,郑丹薇,等.维生素D受体基因rs2222570位点多态性与结核发病相关性的meta分析[J].郑州大学学报(医学版),2016,51(6):774~779. [12] 高亭,蒋引娣,朱波,等.支气管镜下冷冻联合局部注药治疗支气管结核所致气道梗阻的临床分析[J].国际呼吸杂志,2017,37(13):970~973. [13] 孙扬,王瑜玲,张书敏,等.氩等离子体凝固联合冷冻对溃疡型气管支气管结核的疗效分析[J].重庆医学,2017,46(9):1253~1256. [14] Sferopoulos NK. Skin burns following cryotherapy in misdiagnosed pediatric injuries[J]Bodyw Mov Ther, 2018,22(3):556~559.