Abstract：Objective: To analyze the curative effect of aspirin combined with clopidogrel in treatment cerebral infarction and its effect on oxidative stress response and blood rheology. Methods: 106 patients with cerebral infarction were divided into 50 control group and 56 observation group according to the simple random number table. The control group was treated with aspirin, and the observation group was treated with clopidogrel on the basis of the control group. The clinical efficacy, oxidase activity, hemorheology, neurological deficit scale (NIHSS), ability of daily living (ADL), follow-up and incidence of adverse reactions were compared between the two groups. Results: The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) and catalase (CAT) in the two groups decreased 7 and 14 days after treatment, and the changes in the observation group were more significant (P<0.05). NIHSS decreased and ADL scores increased in both groups, and the changes in the observation group were more obvious (P<0.05). The plasma viscosity, whole blood viscosity and platelet aggregation rate of the two groups decreased, and the observation group was lower than the control group (P<0.05). The recurrence rate of the observation group was lower than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Clinical curative effect of aspirin combined with clopidogrel in treatment patients with cerebral infarction is better than aspirin alone, which can reduce oxidative stress response, improve blood rheology and short-term prognosis., and do not increase adverse drug reactions.
李立,王骐,张娜,王媛,曾军燕. 阿司匹林联合氯吡格雷治疗脑梗死的疗效及对氧化应激反应血液流变性的影响[J]. 河北医学, 2018, 24(11): 1922-1925.
LI Li, WANG Qi, ZHANG Na, et al. Effect of Aspirin combined with Clopidogrel on Oxidative Stress and Hemorheology in Patients with Cerebral Infarction. HeBei Med, 2018, 24(11): 1922-1925.
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2018, Vol. 24 
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