阿奇霉素并脂溶性维生素对肺炎支原体肺炎患儿炎性免疫因子的影响

doi:10.3969/j.issn.1006-6233.2018.11.039

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摘要 目的: 研究阿奇霉素并脂溶性维生素(Fatsoluble vitamin,FV)对肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)患儿炎性、免疫因子的影响。方法: 将2014年12月~2017年11月于我院治疗的MPP患儿108例纳入本研究,依据随机数字表法分别纳入联合组与对照组各54例,对照组行常规治疗+阿奇霉素序贯治疗,联合组在对照组基础上联合FV治疗。观察两组症状、体征改善时间以及住院时间。治疗前后血清炎性因子、免疫因子及趋化因子水平。结果: 联合组患儿憋喘、咳嗽、肺部啰音消失时间,退热时间以及住院时间等时间指标均短于对照组(p<0.05)。治疗后,联合组血清IL-8、IL-10、IL-13、TNF-α均低于对照组(P<0.05)。联合组血清C3、C4、IgA、IgM、IgG均低于对照组(P<0.05)。联合组血清CysLTs、MDC、MCP-4均低于对照组(P<0.05)。联合组总有效率(96.30%)高于对照组(77.78%)(P<0.05)。结论: 阿奇霉素并FV可有效清除MPP患儿血清炎性因子,改善血清免疫因子及趋化因子,疗效显著,安全可靠。

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	王荣良

关键词 ：肺炎支原体肺炎, 阿奇霉素, 脂溶性维生素, 炎性因子, 免疫因子

Abstract：Objective: To study the effect of azithromycin combined with fatsoluble vitamin (FV) on inflammatory and immune factors of child patients with mycoplasma pneumoniae pneumonia(MPP). Methods: A total of 108 cases of MPP child patients treated in our hospital from December 2014 to November 2017 were included into this study, and divided into combination group and control group using the random number table method, with 54 cases in each group. Patients in control group were performed conventional therapy plus azithromycin sequential therapy, and based on this, patients in combination group were performed FV trerapy. The symptoms, improvement time of signs, hospitalization time, levels of serum inflammatory factors, immune factors and chemotactic factors before and after treatment of the two groups were observed. Results: The extinction time of dyspnea, cough and lung rale, fever clearance time and hospitalization time in combination group were shorter than those in control group (P<0.05). After treatment, the serum levels of IL-8, IL-10, IL-13 and TNF-α in combination group were lower than those in control group (P<0.05). The serum levels of C3, C4, IgA, IgM and IgG in combination group were lower than those in control group(P<0.05). The serum levels of CysLTs, MDC and MCP-4 in combination group were lower than those in control group (P<0.05). The total effective rate in combination group (96.30%) was higher than 77.78% in control group (P<0.05). Conclusion: Azithromycin combined with FV can effectively remove serum inflammatory factors, improve serum immune factors and chemokines in children with MPP. It is effective, safe and reliable.

Key words： Mycoplasma pneumoniae pneumonia Azithromycin Fatsoluble vitamin Inflammatory factors Immune factors

引用本文:

王荣良. 阿奇霉素并脂溶性维生素对肺炎支原体肺炎患儿炎性免疫因子的影响[J]. 河北医学, 2018, 24(11): 1917-1921.
WANG Rongliang. Effects of Azithromycin combined with Fat Soluble Vitamins on Inflammatory and Immune Factors in Children with Mycoplasma Pneumoniae Pneumonia. HeBei Med, 2018, 24(11): 1917-1921.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.11.039 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I11/1917

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