Abstract：Objective: To investigate the clinical efficacy and related influencing factors of hyperbaric oxygen therapy for severe traumatic brain injury. Methods: Fifty-six patients with severe craniocerebral trauma admitted to our hospital during April 2015 to February 2018 were all treated with hyperbaric oxygen therapy. Their clinical data were retrospectively analyzed and patients were prospectively analyzed with Disability Rating Scale (DRS). Efficacy was assessed and statistical analysis was performed on the relevant influencing factors. Results: Compared with before treatment (25.1±4.7 points), the DRS score (12.7±5.6 points) decreased significantly after treatment (P<0.05); the frequency of hyperbaric oxygen therapy, tracheotomy, basic diseases, The injury site and the number of craniocerebral operations did not significantly affect the long-term outcome of hyperbaric oxygen therapy in severe traumatic brain injury (P>0.05), but the time of hyperbaric oxygen therapy, GCS score on admission, and neurological complications affect this The main factors of long-term curative effect of patients (P<0.05) were treated with hyperbaric oxygen therapy within 29 days after injury. The patients' DRS score was significantly better than that after 30 days. The difference was significant (P<0.05). Conclusion: Hyperbaric oxygen therapy for patients with severe traumatic brain injury can effectively improve the prognosis of patients, including hyperbaric oxygenation time, GCS score at admission,Neurological complications are the main factors affecting the long-term efficacy of patients. The timing of hyperbaric oxygen therapy is the most significant.
鲁友明,陈鑫,张爱军. 重度颅脑外伤应用高压氧治疗的疗效及相关因素分析[J]. 河北医学, 2018, 24(11): 1895-1898.
LU Youming, CHEN Xin, ZHANG Aijun. Efficacy and Related Factors of Hyperbaric Oxygen Therapy for Severe Craniocerebral Trauma. HeBei Med, 2018, 24(11): 1895-1898.
[1] Lubrano R,Elli M,Stoppa F,et al.Variations of the blood gas levels and thermodilutional parameters during ICP monitoring after severe head trauma in children[J].Childs Nerv Syst,2015,31(8):1273~1281. [2] 曹春妮,张祚福,林春华,等.高压氧对重度颅脑外伤患者去骨瓣减压术后并发症及预后的影响[J].中华航海医学与高气压医学杂志.2017,25(1):50~55. [3] 李春雨,郝亚洲,张志强,等.高压氧及右正中神经电刺激对重型颅脑外伤患者的术后催醒探索[J].现代中西医结合杂志.2014,23(24):2661~2663. [4] 刘金志.高压氧联合标准外伤大骨瓣减压手术治疗重型颅脑外伤的预后分析[J].广西医科大学学报.2017,34(1):80~82. [5] Cicuendez M,Castano-Leon A,Ramos A,et al.Prognostic value of corpus callosum injuries in severe head trauma[J].Acta Neurochir(Wien),2017,159(1):25~32. [6] 殷俊,陈磊,朱少锋,等.高压氧联合神经电刺激疗法对颅脑外伤后神经功能的恢复作用[J].中华医学杂志.2015,95(26):2116~2118. [7] Vathanalaoha K,Oearsakul T,Tunthanathip T.Predictive factors of survival and 6-Month favorable outcome of very severe head trauma patients;a historical cohort study[J].Emerg(Tehran),2017,5(1):e24. [8] 张晶晶,金慧君.高压氧联合逐步控制性减压手术对急诊颅脑外伤患者预后的影响[J].中国基层医药.2017,24(9):1343~1347. [9] Mirzaei F,Siahsangi P,Naseri A S.Letter:comment on"can serum glucose level in early admission predict outcome in patients with severe head trauma"[J].World Neurosurg,2016,92:572. [10] 张泽立,刘文明,张源,等.急性脑膨出预防策略对重型颅脑外伤救治的效果分析[J].中华医学杂志.2017,97(31):2435~2438. [11] 高亚南,徐琛,陈雪丽.强化认知训练结合高压氧治疗对颅脑外伤患者认知功能及日常生活活动能力影响的疗效观察[J].北京医学.2015,37(4):388~389. [12] 潘泰峰,罗俊杰,曲新国,等.早期高压氧辅助标准外伤大骨瓣减压手术治疗重型颅脑外损伤的疗效观察[J].广西医科大学学报.2018,35(1):105~108. [13] Khazdouz M,Mazidi M,Ehsaei M R,et al.Impact of zinc supplementation on the clinical outcomes of patients with severe head trauma:a double-blind randomized clinical trial[J].Diet Suppl,2018,15(1):1~10. [14] van den Brink R L,Nieuwenhuis S,van Boxtel G,et al.Task-free spectral EEG dynamics track and predict patient recovery from severe acquired brain injury[J].Neuroimage Clin,2018,17:43~52.
2018, Vol. 24 
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