Abstract：Objective: To investigate the clinical efficacy of Jintian Ge capsule combined with alfacalcidol soft capsules on diabetic osteoporosis and its effect on blood sugar level, clinical symptoms and bone metabolism. Methods: 90 patients with diabetic osteoporosis treated in our hospital from June 2015 to January 2017 were randomly divided into two groups according to the random number table method. The control group was treated with Alfacalcidol Soft Capsules, and the observation group was treated with Jin Tian Ge capsule combined with Alfacalcidol Soft Capsules. After one year of the treatment,the curative effect, adverse reactions, blood sugar, bone pain symptom score, bone metabolism index and bone mineral density were compared between the two groups. Results: The total effective rate of the observation group (91.11%) was higher than that of the control group (75.56%), and the differences was statistically significant(P<0.05), and the levels of FBG and HbALc in the two groups were lower than those before the treatment, and the differences was statistically significant (P<0.05), but there was no significant difference in the level of FBG and HbALc in the two groups (P>0.05). The scores of bone pain symptoms in the two groups were lower than those before the treatment, and the differences was statistically significant (P<0.05), and that of the observation group was lower than that in the control group (P<0.05). The levels of bone alkaline phosphatase in the two groups were lower than before the treatment, and the differences was statistically significant (P<0.05), and the level of bone alkaline phosphatase in the observation group was lower than that of the control group and the level of osteocalcin was higher than that of the control group, and the differences was statistically significant(P<0.05). After treatment, the level of bone alkaline phosphatase in the two groups was lower than that before the treatment and the level of osteocalcin was higher than that before the treatment, and the differences was statistically significant(P<0.05), Tthe level of bone alkaline phosphatase in the observation group was lower than that in the control group, and the level of osteocalcin was higher than that of the control group, and the differences was statistically significant(P<0.05). There was no significant change in the level of blood calcium and blood phosphorus (P>0.05). After treatment, the BMD of femoral trochanter, femur neck and lumbar vertebra in the two groups were higher than that before treatment, and the differences was statistically significant(P<0.05), and the BMD in the observation group were higher than those of the control group, and the differences was statistically significant(P<0.05). The total incidence of adverse reactions in the two groups was not significantly different(P>0.05). Conclusion: The therapeutic effect of Jintian Ge capsule combined with alfacalcidol soft capsules on diabetic osteoporosis is significant. It can effectively relieve the pain symptoms, improve the bone metabolism and the BMD, but it has no effect on blood sugar.
张之梁,任华,庞小芬. 金天格胶囊联合阿法骨化醇软胶囊治疗糖尿病性骨质疏松症的临床研究[J]. 河北医学, 2018, 24(11): 1878-1882.
ZHANG Zhiliang, REN Hua, PANG Xiaofen. Clinical Study of Jintian Ge Capsule combined with Alfacalcidol Soft Capsules in the treatment of Diabetic Osteoporosis. HeBei Med, 2018, 24(11): 1878-1882.
[1] 申玲,刘素萍,朱书朝.阿法骨化醇软胶囊联合雷洛昔芬治疗绝经后骨质疏松症的临床研究[J].现代药物与临床,2017,32(7):1328~1332. [2] 张国建.补肾化瘀方对老年性骨质疏松症肾虚血瘀证证候积分及预后的改善作用[J].湖南中医药大学学报,2017,37(2):200~203. [3] 范名月,李彦.阿托伐他汀联合阿仑膦酸钠治疗老年性骨质疏松症的效果及对患者肿瘤坏死因子α和白细胞介素6的影响[J].中国综合临床,2017,33(4):135~137. [4] 葛均波,徐永健.内科学[M].第8版.人民卫生出版社,2013.733. [5] 何涛.骨质疏松症诊断标准的探讨[J].中国骨质疏松杂志,2010,16(2):151~156. [6] Zhu J, Kong X, Dan W U, et al. Observation of curative effect of GUsong Qianggu decoction on primary osteoporosis of Yang deficiency of kindey and blood stasis type[J]. Modern Journal of Integrated Traditional Chinese & Western Medicine, 2017, 28(7):556~558. [7] 邱奕雁,陈鹏飞,陈扬,等.阿仑膦酸钠片联合阿法骨化醇胶囊治疗围绝经期骨质疏松的临床研究[J].中国临床药理学杂志,2017,33(6):496~498. [8] 付江涛,洪斌,张建林,等.补肾壮骨汤治疗糖尿病性骨质疏松症的临床效果[J].中国医药导报,2017,14(34):332~334. [9] Lv G, Yang H, Liu B, et al. Curative effect of integrated traditional Chinese and western medicine in the treatment of senile osteoporosis[J]. Chinese Community Doctors, 2017, 25(4):446~448.
2018, Vol. 24 
冀公网安备13080202000677号