左卡尼汀重组人促红细胞生长素及铁剂联合治疗血液透析患者的疗效及并发症发生情况分析

doi:10.3969/j.issn.1006-6233.2018.11.026

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摘要 目的: 分析研究左卡尼汀、重组人促红细胞生长素及铁剂联合治疗对血液透析患者的临床疗效及并发症的影响。方法: 选取2017年05月至2018年05月收治的92例血液透析患者为研究对象,依据随机数字表法随机分为对照组(n=46)和观察组(n=46);对照组患者仅给予重组人促红细胞生长素联合铁剂治疗,观察组患者采用左卡尼汀、重组人促红细胞生长素联合铁剂治疗;对比两组患者临床疗效。结果: 治疗后,观察组和对照组患者并发症发生率分别为2.17%(1/46)、15.22%(7/46),两组相比差异具有统计学意义(χ²=4.929,P<0.05)。治疗前,两组患者铁转蛋白饱和度、红细胞比容、血清铁蛋白及血红蛋白等指标相比均无显著性差异(P>0.05);观察组患者治疗后各指标水平与对照组均有明显差异;两组相比差异显著(t=7.107,12.581,38.529,12.024;P<0.05);且观察组患者治疗后血尿素氮、血尿素及血肌酐等指标水平也分别显著低于对照组(t=8.855,18.612,37.383;P<0.05)。结论: 血液透析并发症患者采用左卡尼汀、重组人促红细胞生长素及铁剂联合治疗可以有效的改善患者的临床症状,促进肾功能改善,且不良反应发生率较低,安全性较高,值得临床推广。

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关键词 ：血液透析, 左卡尼汀, 重组人促红细胞生长素, 铁剂

Abstract：Objective: To analyze the effects of combined treatment with L-carnitine, recombinant human erythropoietin and iron on the clinical efficacy and complications of hemodialysis patients. Methods: 92 hemodialysis patients who were admitted to our hospital from May 2017 to May 2018 were selected and randomly divided into control group (n=46) and observation group (n=46) according to the random number table method; Recombinant human erythropoietin and iron were only given. Patients in the observation group were treated with levocarnitine, recombinant human erythropoietin, and iron; clinical efficacy was compared between the two groups. Results: After treatment, the incidence of complications in the observation group and the control group were 2.17% (1/46) and 15.22% (7/46), respectively. The difference between the two groups was statistically significant (χ²= 4.929, P<0.05). Before treatment, there was no significant difference in iron transgenic protein saturation, hematocrit, serum ferritin and hemoglobin between the two groups (P>0.05). The levels of the indicators in the observation group were compared with the control group. The differences between the two groups after treatment were compared, and the differences in improvement were not compared. There were significant differences between the two groups (t=7.107, 12.581, 38.529, 12.024; P<0.05); The levels of blood urea nitrogen, blood urea and serum creatinine were significantly lower in the patients after treatment than in the control group (t=8.855, 18.612, 37.383; P<0.05). Conclusion: The combination of levocarnitine, recombinant human erythropoietin, and iron in patients with hemodialysis complications can effectively improve the clinical symptoms of patients and promote the improvement of renal function. The incidence of adverse reactions is low, and the safety is high. Clinical promotion.

Key words： Hemodialysis L-carnitine Recombinant human erythropoietin Iron

基金资助:江苏省卫生厅科研基金项目,(编号:2016D14070)

引用本文:

董海霞,吕玉风,张定武. 左卡尼汀重组人促红细胞生长素及铁剂联合治疗血液透析患者的疗效及并发症发生情况分析[J]. 河北医学, 2018, 24(11): 1867-1869.
DONG Haixia, LV Yufeng. Efficacy and Complications of Levocarnitine Recombinant Human Erythropoietin and Iron in Hemodialysis Patients. HeBei Med, 2018, 24(11): 1867-1869.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.11.026 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I11/1867

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