Abstract：Objective: To analyze the antihypertensive effect of amlodipine in treatment isolated systolic hypertension and its influences on endothelial cell function. Methods: 92 patients with isolated systolic hypertension who were treated from October 2016 to December 2017 in our hospital were divided into the control group (treated with enalapril) and observation group (treated with amlodipine) according to the simple random number table method with 46 cases in each group. The clinical efficacy, blood pressure changes, vascular endothelial cell function, and adverse reactions in both group were compared. Results: Total effective rate in the observation group was significantly higher than the control group, there was statistical differences (P<0.05). Before treatment, daytime systolic blood pressure (dSBP), average nighttime systolic blood pressure (nSBP) and 24h average systolic blood pressure (24SBP) in both groups were not statistically significant (P>0.05). After treatment of 4 weeks and 6 weeks, dSBP,nSBP,24hSBP in both group were declined, while the observation group decreased more obviously. There was statistically significant differences(P<0.05). Before treatment, the nitric oxide (NO), endothelin-1 (ET-1) and brachial artery flow-mediated vasodilation (FMD) in both groups were no differences. But after treatment of 4 weeks and 6 weeks, NO and FMD in both groups were all rised, ET-1 was decreased, while the observation group changed was more obvious. There was statistically significant differences (P<0.05). Adverse reaction rate in both groups were not statistically significant (P>0.05). Conclusion: Antihypertensive effect is better of amlodipine in treatment isolated systolic hypertension, and it can improve the function of vascular endothelial cells, which can provide reference for clinical blood pressure reduction.
程珂,韩媛,刘文君,于少娟,杨朋康,赵朝. 氨氯地平对单纯收缩期高血压患者的降压效果及对血管内皮细胞功能的影响[J]. 河北医学, 2018, 24(11): 1845-1848.
CHENG Ke, HAN Yuan, LIU Wenjun, et al. Effect of Amlodipine on Blood Pressure and Vascular Endothelial Cell Function in Patients with Isolated Systolic Hypertension. HeBei Med, 2018, 24(11): 1845-1848.
[1] Amsallem M, Boulate D, Aymami M, et al. Load adaptability in patients with pulmonary arterial hypertension[J]. Am Cardiol,2017 ,120(5):874~882. [2] 孟梅, 熊兴东.血管内皮细胞衰老与血管疾病[J].中国生物化学与分子生物学报,2016,32(3):253~259. [3] Ptaszyńska-Kopczyńska K, Krentowska A, Sawicka E, et al. The strengths and weaknesses of non-invasive parameters obtained by echocardiography and cardiopulmonary exercise testing in comparison with the hemodynamic assessment by the right heart catheterization in patients with pulmonary hypertension[J]. Adv Med Sci, 2017,62(1):39~44. [4] Jafar TH, Allen JC, Jehan I, et al. Health Education and General Practitioner Training in Hypertension Management: Long-Term Effects on Kidney Function[J]. Clin Am Soc Nephrol,2016,11(6):1044~1053. [5] 谢进, 胡沛, 李欣,等. 氨氯地平与左旋氨氯地平降压作用及对高血压患者血管内皮功能影响的对比研究[J].实用心脑肺血管病杂志,2016,24(8):63~65. [6] Materson BJ, Garcia-Estrada M, Preston RA. Hypertension in the frail elderly[J].Am Soc Hypertens, 2016,10(6):536~541. [7] Dorofeyeva NA, Kotsuruba AV, Kopjak BS, et al. physical exercise training can- cels constitutive nos uncoupling and induced violations of cardiac hemodynamics in hypertension (PART III)[J]. Fiziol Zh,2015,61(4):11~21. [8] 叶桃春,周小雄,吴辉,等.苯磺酸左旋氨氯地平对单纯收缩期高血压患者血压及变异率的影响[J].广东医学,2017,38(11):1734~1736. [9] 赵洪利,方丽华,李剑,等.老年单纯收缩期高血压最佳治疗方案的探讨[J].中国急救医学,2015,35(s2):64~66. [10] 王燕,李琳,丛伟红,等.原发性高血压与血管内皮功能的相关性分析[J].世界中西医结合杂志,2016,11(3):395~399.
2018, Vol. 24 
冀公网安备13080202000677号