Effect of Carboprost Tromethamine combined with Oxytocin on Postpartum Hemorrhage after Cesarean Section and its Influence on Oxidative Stress and Coagulation Function
HAN Huihui, FENG Chong, HEI Jiangrong
The Affiliated Hospital of Yan'an University, Shaanxi Yanan 716000, China
Abstract：Objective: To study the effect of carboprost tromethamine combined with oxytocin on postpartum hemorrhage after cesarean section and effects on, and oxidative stress and coagulation function. Methods: 130 patients of cesarean section who received therapy from December 2014 to December 2017 in our hospital were selected as research objects, according to random number table, those patients were divided into the observation group (n=65) and the control group (n=65), after the birth of the fetus, the control group was treated with oxytocin, while the observation group was combined with Carboprost Tromethamine. The postpartum hemorrhage, duration of uterine contraction, duration of uterine fundus, lochia duration, stress index, coagulation function and adverse reaction were compared between the two groups. Results: The bleeding volume of 2h and 24h in the observation group was significantly less than that of the control group, the postpartum hemorrhage rate in the observation group was 6.15% (4/65), which was also significantly lower than that in the control group 18.46% (12/65) (P<0.05); the observation group had longer uterine contraction, faster descending rate of uterine fundus, and shorter duration of lochia, compared with the control group, there were significant differences (P<0.05); at the end of operation and at after operation 24h, the malondialdehyde (MDA) in the observation group was significantly lower than that of the control group, and superoxide dismutase (SOD), glutathione peroxidase (GSH-px) and catalase (CAT) were significantly higher than that of the control group(P<0.05); at the end of operation and at after operation 24h, the fibrinogen (FBI), D- two polymer (D-D) in the observation group was significantly lower than that of the control group (P<0.05); there were no significant differences in facial flushing, nausea, vomiting, headache and chest tightness between the two groups(P>0.05). Conclusion: Carboprost tromethamine combined with oxytocin is well for prevention of postpartum hemorrhage in caesarean section, it's helpful for relieving perioperative stress reaction and improve blood coagulation function, and has high safety, it's worthy of application and promotion.
韩慧慧,冯翀,黑江荣. 卡前列素氨丁三醇联合缩宫素对剖宫产产后出血的疗效及对氧化应激凝血功能的影响[J]. 河北医学, 2018, 24(11): 1833-1837.
HAN Huihui, FENG Chong, HEI Jiangrong. Effect of Carboprost Tromethamine combined with Oxytocin on Postpartum Hemorrhage after Cesarean Section and its Influence on Oxidative Stress and Coagulation Function. HeBei Med, 2018, 24(11): 1833-1837.
[1] 张飞雪,牟鸿江,黄太华,等.产后出血的早期识别及预防[J].中国当代医药,2017,24(1):98~100. [3] 卢艳梅.产后大出血急救中的护理配合及其临床效果研究[J].中国计划生育学杂志,2015,23(12):827~829. [3] Kaur MD, Sharma J, Gupta P, et al. Obstetric critical care requirements felt by the obstetricians: An experience-based study[J].Anaesthesiol Clin Pharmacol, 2017, 33(3): 381~386. [4] Caceda SI, Ramos RR, Saborido CM. Pharmacoeconomic study comparing carbetocin with oxytocin for the prevention of hemorrhage following cesarean delivery in Lima, Peru[J].Comp Eff Res, 2018, 7(1): 49~55. [5] 王华鋆.卡前列腺素在妇产科临床中的应用效果分析[J].临床医药文献电子杂志,2017,4(83):16393~16394. [6] Blaser SA, Greif R, Hahnlein KA, et al. Competent management of postpartum haemorrhage: a review on effective training methods[J]. Z Geburtshilfe Neonatol, 2016, 220(3): 106~115. [7] Wu SW, Dian H, Zhang WY. Labor onset, Oxytocin use and epidural anesthesia for vaginal birth after cesarean section and associated effects on maternal and neonatal outcomes in a tertiary hospital in China: a retrospective study[J]. Chin Med (Engl), 2018, 131(8): 933~938. [8] 于芳,孙永林,史海霞.产后出血的药物治疗进展[J].天津药学,2016,28(6):63~66. [9] Bai J, Sun Q, Zhai H. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery[J]. Exp Ther Med, 2014, 7(1): 46~50. [10] 刘桂英.欣母沛对宫缩乏力性产后出血的预防作用观察[J].海南医学院学报,2016,22(19):2315~2317,2321. [11] Balki M, Erik-Soussi M, Ramachandran N, et al. The Contractile Effects of Oxytocin, Ergonovine, and Carboprost and Their Combinations: an In Vitro Study on Human Myometrial Strips[J]. Anesth Analg, 2015, 120(5): 1074~1084. [12] 陈红燕,张世昌,陈黎.卡前列素氨丁三醇预防剖宫产后出血高危产妇的临床效果观察[J].重庆医学,2017,46(33):4628~4632. [13] Sebghati M, Chandraharan E. An update on the risk factors for and management of obstetric haemorrhage[J]. Womens Health (Lond), 2017, 13(2): 34~40. [14] Yamada T, Akaishi R, Oda Y, et al. Antenatal fibrinogen concentrations and postpartum haemorrhage[J]. Int Obstet Anesth, 2014, 23(4): 365~370.
2018, Vol. 24 
冀公网安备13080202000677号