Abstract：Objective: To explore the application of etomidate plasma target controlled infusion combined with sevoflurane anesthesia in gynecological laparoscopic surgery. Methods: From October 2016 to October 2017, 80 cases of patients undergoing elective gynecologic laparoscopic surgery were studied in our hospital. According to the simple random method, the patients were divided into control group and observation group. The control group was treated with propofol by plasma target controlled infusion, and the target controlled infusion of etomidate was used in the observation group. The changes of mean arterial pressure (MAP), heart rate (HR), cognitive function change, awakening period and adverse reaction were compared between the two groups. Results: At the time of T1 and T2, the MAP level of the control group was higher than that of T0 time (P<0.05). When T1, T2 and T3 time, the HR level of the control group was higher than that of the T0 time (P<0.05); there was no statistically significant difference between the observation group and the control group at the time of T0 (P<0.05). The respiratory recovery time, the time of eye opening and extubation in the observation group were significantly shorter than those in the control group (P<0.05). The restlessness score and OAAS score in the observation group were significantly lower than those in the control group (P<0.05). Compared with before anesthesia, MMSE scores were decreased after operation in the two groups (P<0.05); the patients in the observation group after 6h, 24h, 48h, MMSE score higher than the control group (P<0.05). The incidence of adverse reactions in the control group was 22.50%, the incidence of adverse reactions in the observation group was 7.50%, and the incidence of adverse reactions in the observation group was lower than that in the control group (P>0.05). Conclusion: Etomidate plasma target-controlled infusion combined with sevoflurane anesthesia can reduce the influence on circulatory system in patients undergoing gynecological laparoscopic surgery. Moreover, the postoperative anesthesia recovery of this surgical program is faster, less impact on cognitive function of patients, higher safety.
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2018, Vol. 24 
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