新型敷料对骨科感染伤口患者疗效及降钙素原白细胞计数的影响

doi:10.3969/j.issn.1006-6233.2018.11.005

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摘要 目的: 探研新型敷料对骨科感染伤口患者疗效及降钙素原和白细胞计数的影响。方法: 选取2017年1月至2018年1月期间,收治的骨科感染伤口患者80例作为研究对象,其中40例骨科感染伤口患者采用传统干纱布换药为对照组,40例患者采用新型敷料-银离子敷料换药为研究组,对两组患者的临床疗效、治疗前后两组患者降钙素原和白细胞计数的水平变化情况及细胞炎性因子水平的变化情况、两组患者愈合时间、换药次数、住院天数、创面感染率等各项临床指标的改善情况进行评估。结果: 研究组患者的临床疗效显著好于对照组,差异有统计学意义(P<0.05);治疗前两组患者的降钙素原水平无显著差异(P>0.05),治疗后两组患者的降钙素原水平均有所下降,且研究组患者的降钙素原水平下降更为明显,差异有统计学意义(P<0.05);治疗前两组患者的白细胞计数水平无显著差异(P>0.05),治疗后两组患者的白细胞计数水平均有所下降,且研究组患者的白细胞计数水平下降更为显著,差异有统计学意义(P<0.05);治疗前两组患者的各项细胞炎性因子水平无明显差异P>0.05),治疗后研究组患者的各项细胞炎性因子水平改善情况显著好于对照组,差异有统计学意义(P<0.05);研究组患者的愈合时间明显短于对照组、换药次数少于对照组、住院天数少于对照组、创面感染率明显低于对照组,差异有统计学意义(P<0.05)。结论: 在对骨科感染伤口患者进行治疗时,与传统干纱布换药治疗相比,采用新型敷料换药的临床疗效更好,治疗效果更为理想,且可以明显改善患者的降钙素原和白细胞计数水平及各项细胞炎性因子水平,缩短患者的住院时间、减少换药次数、降低伤口感染率,可进一步保障患者的生命健康安全,值得在临床中广泛推广应用。

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	周清洁
	梁云

关键词 ：骨科伤口感染, 新型敷料, 降钙素原

Abstract：Objective: To explore the effect of new dressing on the curative effect and calcitonin and white blood cell count in patients with orthopedic infection. Methods: From January 2017 to January 2018, 80 patients with orthopaedic infectious wounds were selected as the study subjects. 40 patients with orthopaedic infectious wounds were treated with traditional dry gauze dressing change as the control group, and 40 patients were treated with new dressing - silverion dressing change as the study group. The clinical efficacy, procalcitonin and leukocyte counts, cytoinflammatory factors, healing time, times of dressing change, hospitalization days and wound infection rate of the two groups were evaluated. Results: The clinical efficacy of the patients in the study group was significantly better than that in the control group (P<0.05). There was no significant difference in the level of calcitonin in the two groups before the treatment (P > 0.05). After treatment, the average calcitonin water in the two groups was decreased, and the level of calcitonin in the study group was more obvious, the difference was statistical significance (P<0.05); there was no significant difference in the leucocyte count level between the two groups before treatment (P > 0.05). After treatment, the leucocyte count level of the two groups decreased significantly, and the level of leukocyte count decreased more significantly in the study group (P<0.05); the two groups before treatment were statistically significant. There was no significant difference in the level of inflammatory factors (P>0.05). The improvement of inflammatory factors in the patients after treatment was significantly better than that in the control group (P<0.05). The healing time of the patients in the study group was significantly shorter than that of the control group, the number of replacement times was less than the control group, and the number of days in hospital was less than that of the control group. The infection rate of the control group and the wound surface was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion: Compared with the traditional dry gauze dressing change, the new dressing change has better clinical effect and better therapeutic effect in the treatment of orthopedic infectious wounds. And it can improve the level of procalcitonin and leukocyte count and the levels of various cytokines, shorten the hospitalization time, reduce the number of dressing changes, reduce the rate of wound infection, and further protect the life and health of patients. It is worthy to be widely applied in clinical.

Key words： Orthopaedic infection New dressing Calcitonin

基金资助:北京市首都医学发展科研计划项目,(编号:1001690348)

引用本文:

周清洁,梁云. 新型敷料对骨科感染伤口患者疗效及降钙素原白细胞计数的影响[J]. 河北医学, 2018, 24(11): 1777-1781.
ZHOU Qingjie, LIANG Yun. Effect of New Dressing on the Curative Effect of Calcitonin and Leukocyte count in Patients with Orthopedic Infection. HeBei Med, 2018, 24(11): 1777-1781.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.11.005 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I11/1777

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