Abstract：Objective: To investigate the safety and effectiveness of high dose tranexamic acid in spinal surgery. Methods:80 patients admitted to the hospital from October 2015 to October 2017 underwent spine orthopedic surgery were randomly divided into two groups. The patients in the control group followed the normal surgical procedures. Patients in the tranexamic acid group were treated with high doses of tranexamic acid The blood transfusion parameters, Hb, HCT, disease-related parameters and complication were compared between the two groups. Results: The amount of tranexamic acid, autologous erythrocytes, allogeneic red blood cells, fresh frozen plasma FFP, cryoprecipitate, platelets and total transfusion volume of tranexamic acid group were significantly lower than those of the control group. The levels of HCT and HCT at 1 day after operation were significantly higher Which was significantly higher than that of the control group. The APTT level at the end of surgery was significantly lower than that of the control group. The PLT and blood clot time were significantly higher than those of the control group. The postoperative blood transfusion rate was significantly lower than that of the control group (P<0.01). The rate of hypotension was significantly lower than that of the control group (P<0.05). Conclusion: High dose of tranexamic acid used in spinal surgery is clinically effective and safe, with reference value.
时亮,段亮,董向辉. 大剂量氨甲环酸用于脊柱矫形及长节段固定手术的安全性和有效性分析[J]. 河北医学, 2018, 24(10): 1715-1718.
SHI Liang, DUAN Liang, DONG Xianghui. Safety and Efficacy Analysis of High Dose Tranexamic Acid for Spinal Correction and Long Segment Fixation. HeBei Med, 2018, 24(10): 1715-1718.
2018, Vol. 24 
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