Abstract：Objective: To observe the effect of insulin detemir combined with metformin on elderly patients with new onset type 2 diabetes treatment, in order to provide reference for clinical diagnosis and treatment. Methods: The clinical data of elderly patients with newly diagnosed type 2 diabetes in our hospital during the past 2015 to 2016 years were included and analyzed. The patients were divided into observation group (metformin combined with insulin detemir) and control group (metformin). Six months after treatment, total cholesterol (TC), low density lipoprotein (LDL-c), triglyceride (TG), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), glycosylated hemoglobin (HbA1c), insulin resistance index (HOMA-IR) and islet beta cell function index (HOMA-IR) were compared between the two groups. Changes in beta. Results: 45 cases were included in the observation group and 50 cases in the control group. After treatment, both HbA1c and HOMA-IR in the two groups were significantly decreased (P<0.05), but the observation group was significantly lower than the control group (P<0.05). After treatment, the levels of HOMA-β in both groups were significantly higher than those in the control group (P<0.05). After treatment, the levels of TG, TC and LDL-C were decreased in both groups (P<0.05), but those in the observation group were lower than those in the control group (P<0.05). After treatment, the levels of IL-8 and TNF-α in both groups were decreased (P<0.05), while those in the observation group were lower than those in the control group (P<0.05). Conclusion: In the treatment of new type 2 diabetes mellitus in the elderly, insulin detemir combined with metformin is better than metformin alone.
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2018, Vol. 24 
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