Abstract：Objective: To investigate the effect of 5-HT reuptake inhibitors on sleep quality and clinical efficacy in patients with depression. Methods: From June 2016 to May 2018, 124 patients with moderate to severe depression were selected as subjects. They were divided into experimental group (68 cases) and control group (56 cases) by random number table. Patients in the experimental group were treated with 5-HT reuptake inhibitor (SRI), and patients in the control group were treated with tricyclic antidepressants. The overall effectiveness and the Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale (HAMD) and Self-rating Depression Scale (SDS) scores of the two groups after 1, 2 and 4 weeks of treatment were comparative analyzed. Results The overall effective rates of patients in the experimental group after 1, 2 and 4 weeks of treatment were 85.29%, 92.65% and 97.05%, respectively, which were significantly higher than that in the control group with the overall effective rates after treatment were 73.21%, 82.14% and 89.29%, respectively. The difference was statistically significant (P<0.05). In addition, the Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale (HAMD), and Self-rating Depression Scale (SDS) scores were significantly lower in the experimental group than that in the control group after 1, 2 and 4 weeks of treatment and the long-term efficacy of the experimental group was better after treatment for different periods of time. The difference were statistically significant (P<0.05). Conclusion: 5-HT reuptake inhibitors have significant clinical efficacy and safety in patients with depression, which could effectively relieve patients' depressive symptoms and improve their sleep quality, providing a strong theoretical basis for improving the quality of life of depression patients in the future, is worthy for clinical promotion and application.
杨晓钟,马雯霞. 5-HT再摄取抑制剂对抑郁症患者睡眠质量和疗效的影响[J]. 河北医学, 2018, 24(10): 1630-1633.
YANG Xiaozhong, MA Wenxia. The effect of 5-HT Reuptake Inhibitors on Sleep Quality and Clinical Efficacy in Depression Patients. HeBei Med, 2018, 24(10): 1630-1633.
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2018, Vol. 24 
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