Abstract：Objective: To investigate the value of microscopic lung biopsy combined with tumor markers in the diagnosis of lung cancerr. Methods: Using electrochemiluminescence immunoassay for 132 newly diagnosed pulmonary lesions treated in our hospital from April 2013 to September 2017. Serum CEA levels of neuron-specific enolase (NSE), cytokeratin 19 (CYFRA21-1) and squamous cell carcinoma associated antigen (SCC) were detected. At the same time through the electronic bronchoscopy. Results: The levels of serum tumor markers CEA, NSE, CYFRA21-1 and SCC in benign group were significantly lower than those in lung cancer group (P<0.05). The sensitivity of the four combined detection of tumor markers was 80.00%, which was significantly higher than that of individual tumor markers.The difference was statistically significant (P<0.05).The sensitivity of electronic bronchoscopy was 90.00%, and its combined detection with four tumor markers increased the sensitivity to 94.44%. There was no significant difference in the detection specificity of various methods (P>0.05). Conclusion: Electronic bronchoscope combined with tumor markers can effectively increase the detection rate of lung cancer and is worthy of clinical application.
2018, Vol. 24 
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